1hef: Difference between revisions

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[[Image:1hef.jpg|left|200px]]<br /><applet load="1hef" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1hef.jpg|left|200px]]
caption="1hef, resolution 2.20&Aring;" />
 
'''THE CRYSTAL STRUCTURES AT 2.2 ANGSTROMS RESOLUTION OF HYDROXYETHYLENE-BASED INHIBITORS BOUND TO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE SHOW THAT THE INHIBITORS ARE PRESENT IN TWO DISTINCT ORIENTATIONS'''<br />
{{Structure
|PDB= 1hef |SIZE=350|CAPTION= <scene name='initialview01'>1hef</scene>, resolution 2.20&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene>, <scene name='pdbligand=OHE:HYDROXYETHYL+GROUP'>OHE</scene> and <scene name='pdbligand=OME:METHOXY GROUP'>OME</scene>
|ACTIVITY=
|GENE=
}}
 
'''THE CRYSTAL STRUCTURES AT 2.2 ANGSTROMS RESOLUTION OF HYDROXYETHYLENE-BASED INHIBITORS BOUND TO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE SHOW THAT THE INHIBITORS ARE PRESENT IN TWO DISTINCT ORIENTATIONS'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1HEF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=PHE:'>PHE</scene>, <scene name='pdbligand=OHE:'>OHE</scene> and <scene name='pdbligand=OME:'>OME</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEF OCA].  
1HEF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEF OCA].  


==Reference==
==Reference==
The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations., Murthy KH, Winborne EL, Minnich MD, Culp JS, Debouck C, J Biol Chem. 1992 Nov 15;267(32):22770-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1429626 1429626]
The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations., Murthy KH, Winborne EL, Minnich MD, Culp JS, Debouck C, J Biol Chem. 1992 Nov 15;267(32):22770-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1429626 1429626]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: hydrolase(acid proteinase)]]
[[Category: hydrolase(acid proteinase)]]


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