1het: Difference between revisions

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[[Image:1het.gif|left|200px]]<br /><applet load="1het" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1het.gif|left|200px]]
caption="1het, resolution 1.15&Aring;" />
 
'''ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING A HYDROXIDE ADDUCT TO NADH'''<br />
{{Structure
|PDB= 1het |SIZE=350|CAPTION= <scene name='initialview01'>1het</scene>, resolution 1.15&Aring;
|SITE= <scene name='pdbsite=AC3:Zn+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Chain+B'>AC4</scene>, <scene name='pdbsite=NAA:Chain+A+Nucleotide+Binding+Site'>NAA</scene>, <scene name='pdbsite=NAB:Chain+B+Nucleotide+Binding+Site'>NAB</scene>, <scene name='pdbsite=OHA:Active+Site+w.+Zn+Bound+Hydroxide+For+Chain+A'>OHA</scene> and <scene name='pdbsite=OHB:Active+Site+w.+Zn+Bound+Hydroxide+For+Chain+B'>OHB</scene>
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene> and <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]
|GENE=
}}
 
'''ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING A HYDROXIDE ADDUCT TO NADH'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1HET is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=NAD:'>NAD</scene> and <scene name='pdbligand=MRD:'>MRD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] Known structural/functional Sites: <scene name='pdbsite=AC3:Zn+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Chain+B'>AC4</scene>, <scene name='pdbsite=NAA:Chain+A+Nucleotide+Binding+Site'>NAA</scene>, <scene name='pdbsite=NAB:Chain+B+Nucleotide+Binding+Site'>NAB</scene>, <scene name='pdbsite=OHA:Active+Site+w.+Zn+Bound+Hydroxide+For+Chain+A'>OHA</scene> and <scene name='pdbsite=OHB:Active+Site+w.+Zn+Bound+Hydroxide+For+Chain+B'>OHB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HET OCA].  
1HET is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HET OCA].  


==Reference==
==Reference==
On the enzymatic activation of NADH., Meijers R, Morris RJ, Adolph HW, Merli A, Lamzin VS, Cedergren-Zeppezauer ES, J Biol Chem. 2001 Mar 23;276(12):9316-21. Epub 2000 Dec 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11134046 11134046]
On the enzymatic activation of NADH., Meijers R, Morris RJ, Adolph HW, Merli A, Lamzin VS, Cedergren-Zeppezauer ES, J Biol Chem. 2001 Mar 23;276(12):9316-21. Epub 2000 Dec 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11134046 11134046]
[[Category: Alcohol dehydrogenase]]
[[Category: Alcohol dehydrogenase]]
[[Category: Equus caballus]]
[[Category: Equus caballus]]
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[[Category: oxidoreductase(nad(a)-choh(d))]]
[[Category: oxidoreductase(nad(a)-choh(d))]]


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