1x3s: Difference between revisions
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==Crystal structure of human Rab18 in complex with Gppnhp== | |||
<StructureSection load='1x3s' size='340' side='right' caption='[[1x3s]], [[Resolution|resolution]] 1.32Å' scene=''> | |||
== Structural highlights == | |||
==Disease== | <table><tr><td colspan='2'>[[1x3s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X3S FirstGlance]. <br> | ||
[[http://www.uniprot.org/uniprot/RAB18_HUMAN RAB18_HUMAN]] Defects in RAB18 are the cause of Warburg micro syndrome type 3 (WARBM3) [MIM:[http://omim.org/entry/614222 614222]]. WARBM3 is a rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism.<ref>PMID:21473985</ref> | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br> | ||
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
==Function== | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x3s RCSB], [http://www.ebi.ac.uk/pdbsum/1x3s PDBsum], [http://www.topsan.org/Proteins/RSGI/1x3s TOPSAN]</span></td></tr> | ||
[[http://www.uniprot.org/uniprot/RAB18_HUMAN RAB18_HUMAN]] Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.<ref>PMID:21473985</ref> | <table> | ||
== Disease == | |||
== | [[http://www.uniprot.org/uniprot/RAB18_HUMAN RAB18_HUMAN]] Defects in RAB18 are the cause of Warburg micro syndrome type 3 (WARBM3) [MIM:[http://omim.org/entry/614222 614222]]. WARBM3 is a rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism.<ref>PMID:21473985</ref> | ||
[[ | == Function == | ||
[[http://www.uniprot.org/uniprot/RAB18_HUMAN RAB18_HUMAN]] Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.<ref>PMID:21473985</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x3/1x3s_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[GTP-binding protein|GTP-binding protein]] | *[[GTP-binding protein|GTP-binding protein]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chen, L.]] | [[Category: Chen, L.]] | ||
