1hps: Difference between revisions

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[[Image:1hps.jpg|left|200px]]<br /><applet load="1hps" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1hps.jpg|left|200px]]
caption="1hps, resolution 2.3&Aring;" />
 
'''RATIONAL DESIGN, SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P1'-P2' AMIDE BOND ISOSTERE'''<br />
{{Structure
|PDB= 1hps |SIZE=350|CAPTION= <scene name='initialview01'>1hps</scene>, resolution 2.3&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=RUN:2-[(1R,3S,4S)-1-BENZYL-4-[N-(BENZYLOXYCARBONYL)-L-VALYL]AMINO-3-PHENYLPENTYL]-4(5)-(2-METHYLPROPIONYL)IMIDAZOLE'>RUN</scene>
|ACTIVITY=
|GENE=
}}
 
'''RATIONAL DESIGN, SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P1'-P2' AMIDE BOND ISOSTERE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1HPS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=RUN:'>RUN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HPS OCA].  
1HPS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HPS OCA].  


==Reference==
==Reference==
Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'--P2' amide bond isostere., Thompson SK, Murthy KH, Zhao B, Winborne E, Green DW, Fisher SM, DesJarlais RL, Tomaszek TA Jr, Meek TD, Gleason JG, et al., J Med Chem. 1994 Sep 16;37(19):3100-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7932533 7932533]
Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'--P2' amide bond isostere., Thompson SK, Murthy KH, Zhao B, Winborne E, Green DW, Fisher SM, DesJarlais RL, Tomaszek TA Jr, Meek TD, Gleason JG, et al., J Med Chem. 1994 Sep 16;37(19):3100-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7932533 7932533]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: hydrolase(acid proteinase)]]
[[Category: hydrolase(acid proteinase)]]


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