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'''STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION''' | {{Structure | ||
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'''STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1HTM is a [ | 1HTM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Uncultured_beta_proteobacterium_umtra-608 Uncultured beta proteobacterium umtra-608]. The following page contains interesting information on the relation of 1HTM with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb76_1.html Hemagglutinin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. | ||
==Reference== | ==Reference== | ||
Structure of influenza haemagglutinin at the pH of membrane fusion., Bullough PA, Hughson FM, Skehel JJ, Wiley DC, Nature. 1994 Sep 1;371(6492):37-43. PMID:[http:// | Structure of influenza haemagglutinin at the pH of membrane fusion., Bullough PA, Hughson FM, Skehel JJ, Wiley DC, Nature. 1994 Sep 1;371(6492):37-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8072525 8072525] | ||
[[Category: Hemagglutinin]] | [[Category: Hemagglutinin]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: influenza virus hemagglutinin]] | [[Category: influenza virus hemagglutinin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:41:24 2008'' | ||
Revision as of 09:41, 20 March 2008
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STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION
Overview
Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered.
About this Structure
1HTM is a Protein complex structure of sequences from Uncultured beta proteobacterium umtra-608. The following page contains interesting information on the relation of 1HTM with [Hemagglutinin]. Full crystallographic information is available from OCA.
Reference
Structure of influenza haemagglutinin at the pH of membrane fusion., Bullough PA, Hughson FM, Skehel JJ, Wiley DC, Nature. 1994 Sep 1;371(6492):37-43. PMID:8072525
Page seeded by OCA on Thu Mar 20 11:41:24 2008
