2dnf: Difference between revisions
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==Solution structure of RSGI RUH-062, a DCX domain from human== | |||
<StructureSection load='2dnf' size='340' side='right' caption='[[2dnf]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
==Disease== | <table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DNF FirstGlance]. <br> | ||
[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[http://omim.org/entry/600202 600202]]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref> | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DCDC2, KIAA1154 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [http://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [http://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr> | |||
==Function== | <table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[http://omim.org/entry/600202 600202]]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] May be involved in neuronal migration during development of the cerebral neocortex (By similarity). | [[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] May be involved in neuronal migration during development of the cerebral neocortex (By similarity). | ||
== Evolutionary Conservation == | |||
== | [[Image:Consurf_key_small.gif|200px|right]] | ||
[[ | Check<jmol> | ||
<jmolCheckbox> | |||
== | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dnf_consurf.spt"</scriptWhenChecked> | ||
<references | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Hayashi, F.]] | [[Category: Hayashi, F.]] | ||
Revision as of 02:47, 30 September 2014
Solution structure of RSGI RUH-062, a DCX domain from human
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