1hy7: Difference between revisions

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[[Image:1hy7.jpg|left|200px]]<br /><applet load="1hy7" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1hy7.jpg|left|200px]]
caption="1hy7, resolution 1.5&Aring;" />
 
'''A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3'''<br />
{{Structure
|PDB= 1hy7 |SIZE=350|CAPTION= <scene name='initialview01'>1hy7</scene>, resolution 1.5&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=MBS:R-2-{[4'-METHOXY-(1,1'-BIPHENYL)-4-YL]-SULFONYL}-AMINO-6-METHOXY-HEX-4-YNOIC ACID'>MBS</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17]
|GENE= MMP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1HY7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=MBS:'>MBS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HY7 OCA].  
1HY7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HY7 OCA].  


==Reference==
==Reference==
Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines., Natchus MG, Bookland RG, Laufersweiler MJ, Pikul S, Almstead NG, De B, Janusz MJ, Hsieh LC, Gu F, Pokross ME, Patel VS, Garver SM, Peng SX, Branch TM, King SL, Baker TR, Foltz DJ, Mieling GE, J Med Chem. 2001 Mar 29;44(7):1060-71. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11297453 11297453]
Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines., Natchus MG, Bookland RG, Laufersweiler MJ, Pikul S, Almstead NG, De B, Janusz MJ, Hsieh LC, Gu F, Pokross ME, Patel VS, Garver SM, Peng SX, Branch TM, King SL, Baker TR, Foltz DJ, Mieling GE, J Med Chem. 2001 Mar 29;44(7):1060-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11297453 11297453]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: zinc protease]]
[[Category: zinc protease]]


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