1ia2: Difference between revisions

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[[Image:1ia2.gif|left|200px]]<br /><applet load="1ia2" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ia2.gif|left|200px]]
caption="1ia2, resolution 1.82&Aring;" />
 
'''Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE (GW578)'''<br />
{{Structure
|PDB= 1ia2 |SIZE=350|CAPTION= <scene name='initialview01'>1ia2</scene>, resolution 1.82&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TQ4:5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE'>TQ4</scene> and <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC ACID'>MES</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]
|GENE= DFR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans])
}}
 
'''Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE (GW578)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1IA2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans] with <scene name='pdbligand=NDP:'>NDP</scene>, <scene name='pdbligand=TQ4:'>TQ4</scene> and <scene name='pdbligand=MES:'>MES</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IA2 OCA].  
1IA2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IA2 OCA].  


==Reference==
==Reference==
X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor., Whitlow M, Howard AJ, Stewart D, Hardman KD, Chan JH, Baccanari DP, Tansik RL, Hong JS, Kuyper LF, J Med Chem. 2001 Aug 30;44(18):2928-32. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11520201 11520201]
X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor., Whitlow M, Howard AJ, Stewart D, Hardman KD, Chan JH, Baccanari DP, Tansik RL, Hong JS, Kuyper LF, J Med Chem. 2001 Aug 30;44(18):2928-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11520201 11520201]
[[Category: Candida albicans]]
[[Category: Candida albicans]]
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
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[[Category: reductase]]
[[Category: reductase]]


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