1ibc: Difference between revisions

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[[Image:1ibc.gif|left|200px]]<br /><applet load="1ibc" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ibc.gif|left|200px]]
caption="1ibc, resolution 2.73&Aring;" />
 
'''CRYSTAL STRUCTURE OF INHIBITED INTERLEUKIN-1BETA CONVERTING ENZYME'''<br />
{{Structure
|PDB= 1ibc |SIZE=350|CAPTION= <scene name='initialview01'>1ibc</scene>, resolution 2.73&Aring;
|SITE= <scene name='pdbsite=S1:Inhibitor+Binding+Sub-Site+S1'>S1</scene>, <scene name='pdbsite=S2:Inhibitor+Binding+Sub-Site+S2'>S2</scene>, <scene name='pdbsite=S3:Inhibitor+Binding+Sub-Site+S3'>S3</scene> and <scene name='pdbsite=S4:Inhibitor+Binding+Sub-Site+S4'>S4</scene>
|LIGAND= <scene name='pdbligand=ACE:ACETYL GROUP'>ACE</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF INHIBITED INTERLEUKIN-1BETA CONVERTING ENZYME'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1IBC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ACE:'>ACE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] Known structural/functional Sites: <scene name='pdbsite=S1:Inhibitor+Binding+Sub-Site+S1'>S1</scene>, <scene name='pdbsite=S2:Inhibitor+Binding+Sub-Site+S2'>S2</scene>, <scene name='pdbsite=S3:Inhibitor+Binding+Sub-Site+S3'>S3</scene> and <scene name='pdbsite=S4:Inhibitor+Binding+Sub-Site+S4'>S4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IBC OCA].  
1IBC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IBC OCA].  


==Reference==
==Reference==
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)., Rano TA, Timkey T, Peterson EP, Rotonda J, Nicholson DW, Becker JW, Chapman KT, Thornberry NA, Chem Biol. 1997 Feb;4(2):149-55. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9190289 9190289]
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)., Rano TA, Timkey T, Peterson EP, Rotonda J, Nicholson DW, Becker JW, Chapman KT, Thornberry NA, Chem Biol. 1997 Feb;4(2):149-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9190289 9190289]
[[Category: Caspase-1]]
[[Category: Caspase-1]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: protease]]
[[Category: protease]]


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