2of6: Difference between revisions
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[[ | ==Structure of immature West Nile virus== | ||
<StructureSection load='2of6' size='340' side='right' caption='[[2of6]], [[Resolution|resolution]] 24.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2of6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OF6 FirstGlance]. <br> | |||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2of6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2of6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2of6 RCSB], [http://www.ebi.ac.uk/pdbsum/2of6 PDBsum]</span></td></tr> | |||
<table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The structure of immature West Nile virus particles, propagated in the presence of ammonium chloride to block virus maturation in the low-pH environment of the trans-Golgi network, was determined by cryo-electron microscopy (cryo-EM). The structure of these particles was similar to that of immature West Nile virus particles found as a minor component of mature virus samples (naturally occurring immature particles [NOIPs]). The structures of mature infectious flaviviruses are radically different from those of the immature particles. The similarity of the ammonium chloride-treated particles and NOIPs suggests either that the NOIPs have not undergone any conformational change during maturation or that the conformational change is reversible. Comparison with the cryo-EM reconstruction of immature dengue virus established the locations of the N-linked glycosylation sites of these viruses, verifying the interpretation of the reconstructions of the immature flaviviruses. | |||
Structure of immature West Nile virus.,Zhang Y, Kaufmann B, Chipman PR, Kuhn RJ, Rossmann MG J Virol. 2007 Jun;81(11):6141-5. Epub 2007 Mar 21. PMID:17376919<ref>PMID:17376919</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
*[[Heat Shock Proteins|Heat Shock Proteins]] | *[[Heat Shock Proteins|Heat Shock Proteins]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: West nile virus]] | [[Category: West nile virus]] | ||
[[Category: Chipman, P R.]] | [[Category: Chipman, P R.]] | ||
Revision as of 01:03, 2 October 2014
Structure of immature West Nile virus
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