1j3i: Difference between revisions

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[[Image:1j3i.gif|left|200px]]~~<br /><applet load~~="1j3i~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1j3i.gif|left|200px]]

~~caption="~~1j3i, resolution 2.33Å" />

'''Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP'''~~<br />~~

{{Structure

|PDB= 1j3i |SIZE=350|CAPTION= <scene name='initialview01'>1j3i</scene>, resolution 2.33Å

|SITE=

|LIGAND= <scene name='pdbligand=WRA:6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>WRA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=UMP:2'-DEOXYURIDINE 5'-MONOPHOSPHATE'>UMP</scene>

|ACTIVITY=

|GENE=

}}

'''Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP'''

==Overview==

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==About this Structure==

1J3I is a [~~http://en.wikipedia.org/wiki/Protein_complex~~ Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum~~] with <scene name='pdbligand=WRA:'>WRA</scene>, <scene name='pdbligand=NDP:'>NDP</scene> and <scene name='pdbligand=UMP:'>UMP</scene> as [http://en.wikipedia.org/wiki/ligands ligands~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3I OCA].

1J3I is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3I OCA].

==Reference==

Insights into antifolate resistance from malarial DHFR-TS structures., Yuvaniyama J, Chitnumsub P, Kamchonwongpaisan S, Vanichtanankul J, Sirawaraporn W, Taylor P, Walkinshaw MD, Yuthavong Y, Nat Struct Biol. 2003 May;10(5):357-65. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~12704428 12704428]

Insights into antifolate resistance from malarial DHFR-TS structures., Yuvaniyama J, Chitnumsub P, Kamchonwongpaisan S, Vanichtanankul J, Sirawaraporn W, Taylor P, Walkinshaw MD, Yuthavong Y, Nat Struct Biol. 2003 May;10(5):357-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12704428 12704428]

[[Category: Plasmodium falciparum]]

[[Category: Protein complex]]

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[[Category: bifunctional]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 13~~:18:33 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:58:27 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1j3i.gif|left|200px]]<br /><applet load="1j3i" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1j3i.gif|left|200px]]
-caption="1j3i, resolution 2.33&Aring;" />
-'''Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP'''<br />
+ {{Structure
+|PDB= 1j3i |SIZE=350|CAPTION= <scene name='initialview01'>1j3i</scene>, resolution 2.33&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=WRA:6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>WRA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=UMP:2'-DEOXYURIDINE 5'-MONOPHOSPHATE'>UMP</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-J3I is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] with <scene name='pdbligand=WRA:'>WRA</scene>, <scene name='pdbligand=NDP:'>NDP</scene> and <scene name='pdbligand=UMP:'>UMP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3I OCA].
+J3I is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3I OCA].
 ==Reference==
-Insights into antifolate resistance from malarial DHFR-TS structures., Yuvaniyama J, Chitnumsub P, Kamchonwongpaisan S, Vanichtanankul J, Sirawaraporn W, Taylor P, Walkinshaw MD, Yuthavong Y, Nat Struct Biol. 2003 May;10(5):357-65. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12704428 12704428]
+Insights into antifolate resistance from malarial DHFR-TS structures., Yuvaniyama J, Chitnumsub P, Kamchonwongpaisan S, Vanichtanankul J, Sirawaraporn W, Taylor P, Walkinshaw MD, Yuthavong Y, Nat Struct Biol. 2003 May;10(5):357-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12704428 12704428]
 [[Category: Plasmodium falciparum]]
 [[Category: Protein complex]]
@@ Line 26: / Line 35: @@
 [[Category: bifunctional]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:18:33 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:58:27 2008''