4v10: Difference between revisions
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''' | ==Skelemin Association with alfa2b,betta3 Integrin: A Structural Model== | ||
<StructureSection load='4v10' size='340' side='right' caption='[[4v10]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4v10]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V10 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v10 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v10 RCSB], [http://www.ebi.ac.uk/pdbsum/4v10 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Over the last two decades, our knowledge concerning intracellular events that regulate integrin's affinity to their soluble ligands has significantly improved. However, the mechanism of adhesion-induced integrin clustering and development of focal complexes, which could further mature to form focal adhesions, still remains under-investigated. Here we present a structural model of tandem IgC2 domains of skelemin in complex with the cytoplasmic tails of integrin alphaIIbbeta3. The model is generated based upon NMR data and this tertiary assembly illuminates a potential link between the essential cell adhesion receptors and myosin filaments. This connection may serve as a basis for generating the mechanical forces necessary for cell migration and remodeling. | |||
Skelemin Association with AlphaIIbBeta3 Integrin: A Structural Model.,Gorbatyuk V, Nguyen K, Podolnikova NP, Deshmukh L, Lin X, Ugarova TP, Vinogradova O Biochemistry. 2014 Sep 15. PMID:25224262<ref>PMID:25224262</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Deshmukh, L.]] | |||
[[Category: Gorbatyuk, V.]] | |||
[[Category: Nguyen, K.]] | |||
[[Category: Vinogradova, O.]] | |||
[[Category: Integrin]] | |||
[[Category: Structural protein]] | |||
Revision as of 07:39, 8 October 2014
Skelemin Association with alfa2b,betta3 Integrin: A Structural Model
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