1jes: Difference between revisions
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[[Image:1jes.gif|left|200px]] | [[Image:1jes.gif|left|200px]] | ||
'''Crystal Structure of a Copper-Mediated Base Pair in DNA''' | {{Structure | ||
|PDB= 1jes |SIZE=350|CAPTION= <scene name='initialview01'>1jes</scene>, resolution 1.5Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CU:COPPER (II) ION'>CU</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Crystal Structure of a Copper-Mediated Base Pair in DNA''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1JES is a [ | 1JES is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JES OCA]. | ||
==Reference== | ==Reference== | ||
Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:[http:// | Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11734038 11734038] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Atwell, S.]] | [[Category: Atwell, S.]] | ||
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[[Category: z-dna]] | [[Category: z-dna]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:02:28 2008'' | ||
Revision as of 10:02, 20 March 2008
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| 1jes, resolution 1.5Å | |||||||||||||
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| Ligands: | CU | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal Structure of a Copper-Mediated Base Pair in DNA
Overview
Stable and selective DNA base pairing by metal coordination was recently demonstrated with nucleotides containing complementary pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.; Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am. Chem. Soc. 2000, 122, 10714-10715). To understand the structural consequences of introducing this novel base pair into DNA we have solved the crystal structure of a duplex containing the metallo-base pair. The structure shows that the bases pair as designed, but in a Z-DNA conformation. The structure also provides a structural explanation for the B- to Z-DNA transition in this duplex. Further solution studies demonstrate that the metallo-base pair is compatible with Z- or B-DNA conformations, depending on the duplex sequence.
About this Structure
1JES is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:11734038
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