2il9: Difference between revisions

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[[~~Image~~:2il9.~~png|left|200px~~]]

==Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms==

== Structural highlights ==

<table><tr><td colspan='2'>[[2il9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IL9 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2il9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2il9 RCSB], [http://www.ebi.ac.uk/pdbsum/2il9 PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Canonical cap-dependent translation initiation requires a large number of protein factors that act in a stepwise assembly process. In contrast, internal ribosomal entry sites (IRESs) are cis-acting RNAs that in some cases completely supplant these factors by recruiting and activating the ribosome using a single structured RNA. Here we present the crystal structures of the ribosome-binding domain from a Dicistroviridae intergenic region IRES at 3.1 angstrom resolution, providing a view of the prefolded architecture of an all-RNA translation initiation apparatus. Docking of the structure into cryo-electron microscopy reconstructions of an IRES-ribosome complex suggests a model for ribosome manipulation by a dynamic IRES RNA.

~~{{STRUCTURE_2il9| PDB=2il9 | SCENE= }}~~

Structural basis for ribosome recruitment and manipulation by a viral IRES RNA.,Pfingsten JS, Costantino DA, Kieft JS Science. 2006 Dec 1;314(5804):1450-4. Epub 2006 Nov 23. PMID:17124290<ref>PMID:17124290</ref>

~~===Crystal Structure~~ of ~~Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3~~.~~1 Angstroms===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_17124290}}~~

== References ==

==~~About this Structure~~==

__TOC__

~~[[2il9]] is a 2 chain structure. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=2IL9 OCA].~~

</StructureSection>

[[Category: Costantino, D A.]]

[[Category: Kieft, J S.]]

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-[[Image:2il9.png|left|200px]]
+==Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms==
+<StructureSection load='2il9' size='340' side='right' caption='[[2il9]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2il9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IL9 FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2il9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2il9 RCSB], [http://www.ebi.ac.uk/pdbsum/2il9 PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Canonical cap-dependent translation initiation requires a large number of protein factors that act in a stepwise assembly process. In contrast, internal ribosomal entry sites (IRESs) are cis-acting RNAs that in some cases completely supplant these factors by recruiting and activating the ribosome using a single structured RNA. Here we present the crystal structures of the ribosome-binding domain from a Dicistroviridae intergenic region IRES at 3.1 angstrom resolution, providing a view of the prefolded architecture of an all-RNA translation initiation apparatus. Docking of the structure into cryo-electron microscopy reconstructions of an IRES-ribosome complex suggests a model for ribosome manipulation by a dynamic IRES RNA.
-{{STRUCTURE_2il9|  PDB=2il9  |  SCENE=  }}
+Structural basis for ribosome recruitment and manipulation by a viral IRES RNA.,Pfingsten JS, Costantino DA, Kieft JS Science. 2006 Dec 1;314(5804):1450-4. Epub 2006 Nov 23. PMID:17124290<ref>PMID:17124290</ref>
-===Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_17124290}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[2il9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL9 OCA].
+</StructureSection>
 [[Category: Costantino, D A.]]
 [[Category: Kieft, J S.]]