2kmj: Difference between revisions

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[[~~Image~~:2kmj.~~png|left|200px~~]]

==High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry==

== Structural highlights ==

<table><tr><td colspan='2'>[[2kmj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_2 Human immunodeficiency virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KMJ FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZUK:5-PYRIMIDIN-2-YL-D-NORVALINE'>ZUK</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kmj RCSB], [http://www.ebi.ac.uk/pdbsum/2kmj PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Target TAR by NMR: Tripeptides containing arginines as terminal residues and non-natural amino acids as central residues are good leads for drug design to target the HIV trans-activation response element (TAR). The structural characterization of the RNA-ligand complex by NMR spectroscopy reveals two specific binding sites that are located at bulge residue U23 and around the pyrimidine-stretch U40-C41-U42 directly adjacent to the bulge.

~~{{STRUCTURE_2kmj| PDB=2kmj | SCENE= }}~~

Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.,Ferner J, Suhartono M, Breitung S, Jonker HR, Hennig M, Wohnert J, Gobel M, Schwalbe H Chembiochem. 2009 Jun 15;10(9):1490-4. PMID:19444830<ref>PMID:19444830</ref>

~~===High resolution NMR solution structure of~~ a ~~complex~~ of ~~HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_19444830}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[2kmj]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human_immunodeficiency_virus_2 Human immunodeficiency virus 2]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2KMJ OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:019444830<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Human immunodeficiency virus 2]]

[[Category: Breitung, S.]]

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-[[Image:2kmj.png|left|200px]]
+==High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry==
+<StructureSection load='2kmj' size='340' side='right' caption='[[2kmj]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2kmj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_2 Human immunodeficiency virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KMJ FirstGlance]. <br>
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZUK:5-PYRIMIDIN-2-YL-D-NORVALINE'>ZUK</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kmj RCSB], [http://www.ebi.ac.uk/pdbsum/2kmj PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Target TAR by NMR: Tripeptides containing arginines as terminal residues and non-natural amino acids as central residues are good leads for drug design to target the HIV trans-activation response element (TAR). The structural characterization of the RNA-ligand complex by NMR spectroscopy reveals two specific binding sites that are located at bulge residue U23 and around the pyrimidine-stretch U40-C41-U42 directly adjacent to the bulge.
-{{STRUCTURE_2kmj|  PDB=2kmj  |  SCENE=  }}
+Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.,Ferner J, Suhartono M, Breitung S, Jonker HR, Hennig M, Wohnert J, Gobel M, Schwalbe H Chembiochem. 2009 Jun 15;10(9):1490-4. PMID:19444830<ref>PMID:19444830</ref>
-===High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_19444830}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[2kmj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_2 Human immunodeficiency virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMJ OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:019444830</ref><references group="xtra"/>
 [[Category: Human immunodeficiency virus 2]]
 [[Category: Breitung, S.]]