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[[Image:2hdz.png|left|200px]]
==Crystal Structure Analysis of the UBF HMG box5==
<StructureSection load='2hdz' size='340' side='right' caption='[[2hdz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2hdz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HDZ FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hdz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hdz RCSB], [http://www.ebi.ac.uk/pdbsum/2hdz PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The fifth HMG-box domain in human upstream binding factor (hUBF) contributes to the synthesis of rRNA by RNA polymerase I (Pol I). The 2.0 A resolution crystal structure of this protein has been solved using the single-wavelength anomalous dispersion method (SAD). The crystal structure and the reported NMR structure have r.m.s. deviations of 2.18-3.03 A for the C(alpha) atoms. However, there are significant differences between the two structures, with displacements of up to 9.0 A. Compared with other HMG-box structures, the r.m.s. deviations for C(alpha) atoms between hUBF HMG box 5 and HMG domains from Drosophila melanogaster protein D and Rattus norvegicus HMG1 are 1.5 and 1.6 A, respectively. This indicates that the differences between the crystal and NMR structures of hUBF HMG box 5 are larger than those with its homologous structures. The differences between the two structures potentially reflect two states with different structures. The specific interactions between the hUBF HMG box 5 and the first bromodomain of TBP-associated factor 1 (TAF1) were studied by ultrasensitive differential scanning calorimetry and chemical shift perturbation. Based on these experimental data, possible sites in hUBF HMG box 5 that may interact with the first bromodomain of TAF1 were proposed.


{{STRUCTURE_2hdz|  PDB=2hdz  |  SCENE=  }}
Structure of human upstream binding factor HMG box 5 and site for binding of the cell-cycle regulatory factor TAF1.,Rong H, Li Y, Shi X, Zhang X, Gao Y, Dai H, Teng M, Niu L, Liu Q, Hao Q Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):730-7. Epub 2007, May 15. PMID:17505112<ref>PMID:17505112</ref>


===Crystal Structure Analysis of the UBF HMG box5===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_17505112}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[2hdz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDZ OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:017505112</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Niu, L W.]]
[[Category: Niu, L W.]]
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