2g9l: Difference between revisions
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[[ | ==The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction== | ||
<StructureSection load='2g9l' size='340' side='right' caption='[[2g9l]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2g9l]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G9L FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g9l RCSB], [http://www.ebi.ac.uk/pdbsum/2g9l PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We have applied NMR spectroscopy to determine the high-resolution structure of gaegurin 4, a 37-residue antimicrobial peptide from Rana rugosa, under varying hydrophobic conditions. Even in 100% H2O, gaegurin 4 contains a nascent turn near its C-terminal Rana box. Under a more hydrophobic condition it forms two amphipathic helices, one long encompassing residues 2-23 and the other consisting of residues 25-34, similar to what has been observed in cecropin A. Functional implication of the helix-breaking kink at Gly24 in gaegurin 4 was investigated by preparing several analogs. Based upon the current and previous results, we propose a novel seaanemone-like ion pore-forming model for gaegurin 4. | |||
Solution structure and membrane interaction mode of an antimicrobial peptide gaegurin 4.,Chi SW, Kim JS, Kim DH, Lee SH, Park YH, Han KH Biochem Biophys Res Commun. 2007 Jan 19;352(3):592-7. Epub 2006 Nov 27. PMID:17141187<ref>PMID:17141187</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Chi, S W.]] | [[Category: Chi, S W.]] | ||
[[Category: Han, K H.]] | [[Category: Han, K H.]] | ||
[[Category: Amphipathic helix]] | [[Category: Amphipathic helix]] | ||
[[Category: Antibiotic]] | [[Category: Antibiotic]] | ||
Revision as of 15:32, 12 October 2014
The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction
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