2jym: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "2jym" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
[[ | ==Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element== | ||
<StructureSection load='2jym' size='340' side='right' caption='[[2jym]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2jym]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JYM FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jym OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jym RCSB], [http://www.ebi.ac.uk/pdbsum/2jym PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Chronic hepatitis B virus (HBV) infections may lead to severe diseases like liver cirrhosis or hepatocellular carcinoma (HCC). The HBV post-transcriptional regulatory element (HPRE) facilitates the nuclear export of unspliced viral mRNAs, contains a splicing regulatory element and resides in the 3'-region of all viral transcripts. The HPRE consists of three sub-elements alpha (nucleotides 1151-1346), beta1 (nucleotides 1347-1457) and beta2 (nucleotides 1458-1582), which confer together full export competence. Here, we present the NMR solution structure (pdb 2JYM) of the stem-loop alpha (SLalpha, nucleotides 1292-1321) located in the sub-element alpha. The SLalpha contains a CAGGC pentaloop highly conserved in hepatoviruses, which essentially adopts a CUNG-like tetraloop conformation. Furthermore, the SLalpha harbours a single bulged G residue flanked by A-helical regions. The structure is highly suggestive of serving two functions in the context of export of unspliced viral RNA: binding sterile alpha motif (SAM-) domain containing proteins and/or preventing the utilization of a 3'-splice site contained within SLalpha. | |||
Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element.,Schwalbe M, Ohlenschlager O, Marchanka A, Ramachandran R, Hafner S, Heise T, Gorlach M Nucleic Acids Res. 2008 Mar;36(5):1681-9. Epub 2008 Feb 7. PMID:18263618<ref>PMID:18263618</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Gorlach, M.]] | [[Category: Gorlach, M.]] | ||
[[Category: Ohlenschlager, O.]] | [[Category: Ohlenschlager, O.]] | ||
Revision as of 15:36, 12 October 2014
Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element
| ||||||||||||
