VP24: Difference between revisions
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== Function == | == Function == | ||
'''Ebola''' | |||
In a normal immune response interferons (IFN) are produced to alert surrounding cells of the presence of a pathogen. This response activates STAT1, which increases production of immune fighting genes in cells, by phosphorylation. STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 binds to karyopherin α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result the immune response in cells is then greatly weakened. | In a normal immune response interferons (IFN) are produced to alert surrounding cells of the presence of a pathogen. This response activates STAT1, which increases production of immune fighting genes in cells, by phosphorylation. STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 binds to karyopherin α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result the immune response in cells is then greatly weakened. | ||
'''Marburg''' | |||
== Structural Characteristics == | == Structural Characteristics == | ||
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<scene name='60/602719/Vp24_chain_a_from_reston_virus/1'>Chain A</scene> | <scene name='60/602719/Vp24_chain_a_from_reston_virus/1'>Chain A</scene> | ||
<scene name='60/602719/Chain_b/1'> | <scene name='60/602719/Chain_b/1'>Chain B</scene> | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
