Telomerase: Difference between revisions

<scene name='60/602706/Tert_catalytic_subunit/1'>TERT catalytic subunit</scene> contains 3 domains: reverse transcriptase domain (in green), and carboxy-terminal extension (CTE)(in blue), RNA binding domain (TRBD)(in red). Similar to its structural homologs, as noted above, the ring contains fingers, palm, and thumb sections. The reverse transcriptase domain represents the fingers and palm. It consists of a mixture of alpha helices and beta strands The TRBD domain is a helical structure that binds double and single stranded RNA, and is essential for RNP assembly and repeat addition processivity. This fingers and palm is one of the most conserved portions across similar phylogeny. The thumb corresponds to the CTE, which is an elongated helical bundle that contains several surface-exposed long loops. Lastly, the TRBD is a helical structure that binds double and single stranded RNA. CTE and TRBD, the two terminal ends of the protein come together to form the ring-like structure.