1jnp: Difference between revisions
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'''Crystal Structure of Murine Tcl1 at 2.5 Resolution''' | {{Structure | ||
|PDB= 1jnp |SIZE=350|CAPTION= <scene name='initialview01'>1jnp</scene>, resolution 2.50Å | |||
|SITE= | |||
|LIGAND= | |||
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|GENE= | |||
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'''Crystal Structure of Murine Tcl1 at 2.5 Resolution''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1JNP is a [ | 1JNP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNP OCA]. | ||
==Reference== | ==Reference== | ||
Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family., Petock JM, Torshin IY, Wang YF, Du Bois GC, Croce CM, Harrison RW, Weber IT, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1545-51. Epub 2001, Oct 25. PMID:[http:// | Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family., Petock JM, Torshin IY, Wang YF, Du Bois GC, Croce CM, Harrison RW, Weber IT, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1545-51. Epub 2001, Oct 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11679718 11679718] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: dimer]] | [[Category: dimer]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:05:51 2008'' | ||
Revision as of 10:05, 20 March 2008
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| 1jnp, resolution 2.50Å | |||||||||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal Structure of Murine Tcl1 at 2.5 Resolution
Overview
Tcl1 and Mtcp1, members of the Tcl1 family, are implicated in T-cell prolymphocytic leukemia. The crystal structure of a dimer of murine Tcl1 has been determined at 2.5 A resolution with an R factor of 0.225. Murine Tcl1, human Tcl1 and Mtcp1 share very similar subunit structures, with RMS differences of 0.6 and 1.4 A for C(alpha) atoms, respectively, while the sequences share 50 and 36% identity, respectively. These structures fold into an eight-stranded beta-barrel of unique topology and high internal symmetry of 1.1-1.3 A for the two halves of human and murine Tcl1 and 1.7 A for Mtcp1, despite the low 12-13% sequence identity. The molecular surfaces of all three structures showed a common planar region which is likely to be involved in protein-protein interactions.
About this Structure
1JNP is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family., Petock JM, Torshin IY, Wang YF, Du Bois GC, Croce CM, Harrison RW, Weber IT, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1545-51. Epub 2001, Oct 25. PMID:11679718
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