1jom: Difference between revisions

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[[Image:1jom.gif|left|200px]]<br /><applet load="1jom" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1jom.gif|left|200px]]
caption="1jom, resolution 1.90&Aring;" />
 
'''THE CRYSTAL STRUCTURE OF THE BINARY COMPLEX BETWEEN FOLINIC ACID (LEUCOVORIN) AND E. COLI DIHYDROFOLATE REDUCTASE'''<br />
{{Structure
|PDB= 1jom |SIZE=350|CAPTION= <scene name='initialview01'>1jom</scene>, resolution 1.90&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FFO:5-FORMYL-6-HYDROFOLIC+ACID'>FFO</scene> and <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]
|GENE=
}}
 
'''THE CRYSTAL STRUCTURE OF THE BINARY COMPLEX BETWEEN FOLINIC ACID (LEUCOVORIN) AND E. COLI DIHYDROFOLATE REDUCTASE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1JOM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=FFO:'>FFO</scene> and <scene name='pdbligand=EOH:'>EOH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOM OCA].  
1JOM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOM OCA].  


==Reference==
==Reference==
Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4., Lee H, Reyes VM, Kraut J, Biochemistry. 1996 Jun 4;35(22):7012-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8679526 8679526]
Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4., Lee H, Reyes VM, Kraut J, Biochemistry. 1996 Jun 4;35(22):7012-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8679526 8679526]
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: one-carbon metabolism oxidoreductase]]
[[Category: one-carbon metabolism oxidoreductase]]


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