4p7s: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==Crystal structure of PfMIF in complex with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine==

== Structural highlights ==

<table><tr><td colspan='2'>[[4p7s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P7S FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OK:4-(3-METHOXY-5-METHYLPHENOXY)-2-(4-METHOXYPHENYL)-6-METHYLPYRIDINE'>2OK</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p7m|4p7m]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p7s RCSB], [http://www.ebi.ac.uk/pdbsum/4p7s PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

We report the crystal structures of two inhibitors of Plasmodium falciparum macrophage migration inhibitory factor (PfMIF) with nanomolar Ki's, analyze their interactions with the active site of PfMIF, and provide explanations regarding their selectivity of PfMIF versus human MIF. These inhibitors were also found to selectively inhibit interactions between PfMIF and the human MIF receptor CD74. The results of this study provide the framework for the development of new therapeutics that target PfMIF.

~~The entry 4p7s is ON HOLD until Paper Publication~~

Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors.,Pantouris G, Rajasekaran D, Garcia AB, Ruiz VG, Leng L, Jorgensen WL, Bucala R, Lolis EJ J Med Chem. 2014 Oct 8. PMID:25268646<ref>PMID:25268646</ref>

~~Authors: Pantouris~~, G., Lolis, E.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~Description~~: ~~Crystal structure of PfMIF in~~ complex ~~with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine~~

== References ==

__TOC__

</StructureSection>

[[Category: Lolis, E.]]

[[Category: Pantouris, G.]]

[[Category: Cytokine-inhibitor complex]]

[[Category: Inhibitor]]

[[Category: Malaria complex active site]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of PfMIF in complex with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine==
+<StructureSection load='4p7s' size='340' side='right' caption='[[4p7s]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4p7s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P7S FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OK:4-(3-METHOXY-5-METHYLPHENOXY)-2-(4-METHOXYPHENYL)-6-METHYLPYRIDINE'>2OK</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p7m|4p7m]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p7s RCSB], [http://www.ebi.ac.uk/pdbsum/4p7s PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We report the crystal structures of two inhibitors of Plasmodium falciparum macrophage migration inhibitory factor (PfMIF) with nanomolar Ki's, analyze their interactions with the active site of PfMIF, and provide explanations regarding their selectivity of PfMIF versus human MIF. These inhibitors were also found to selectively inhibit interactions between PfMIF and the human MIF receptor CD74. The results of this study provide the framework for the development of new therapeutics that target PfMIF.
-The entry 4p7s is ON HOLD  until Paper Publication
+Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors.,Pantouris G, Rajasekaran D, Garcia AB, Ruiz VG, Leng L, Jorgensen WL, Bucala R, Lolis EJ J Med Chem. 2014 Oct 8. PMID:25268646<ref>PMID:25268646</ref>
-Authors: Pantouris, G., Lolis, E.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: Crystal structure of PfMIF in complex with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Lolis, E.]]
+[[Category: Pantouris, G.]]
+[[Category: Cytokine-inhibitor complex]]
+[[Category: Inhibitor]]
+[[Category: Malaria complex active site]]