4rg2: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Tudor Domain of Tumor suppressor p53BP1 with small molecule ligand==

~~The entry~~ 4rg2 is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4rg2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RG2 FirstGlance]. <br>

~~Authors~~: ~~Dong~~, A., ~~Mader~~, P., ~~Ingerman~~, L., ~~Tempel, W~~., ~~Frye, S~~., Bountra, C., ~~Arrowsmith~~, C.~~H.,~~ Edwards, A.M., ~~Brown~~, P.J., Structural Genomics Consortium ~~(SGC)~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3OO:3-BROMO-N-[3-(TERT-BUTYLAMINO)PROPYL]BENZAMIDE'>3OO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rg2 RCSB], [http://www.ebi.ac.uk/pdbsum/4rg2 PDBsum]</span></td></tr>

~~Description~~: ~~Tudor Domain of Tumor suppressor p53BP1 with small molecule ligand~~

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.

== Function ==

[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Arrowsmith, C H.]]

[[Category: Bountra, C.]]

[[Category: Brown, P J.]]

[[Category: Dong, A.]]

[[Category: Edwards, A M.]]

[[Category: Frye, S.]]

[[Category: James, L.]]

[[Category: Mader, P.]]

[[Category: Perfetti, M.]]

[[Category: SGC, Structural Genomics Consortium.]]

[[Category: Tempel, W.]]

[[Category: 53bp1 tudor]]

[[Category: Sgc]]

[[Category: Structural genomic]]

[[Category: Structural genomics consortium]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Tudor Domain of Tumor suppressor p53BP1 with small molecule ligand==
+<StructureSection load='4rg2' size='340' side='right' caption='[[4rg2]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-The entry 4rg2 is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rg2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RG2 FirstGlance]. <br>
-Authors: Dong, A., Mader, P., Ingerman, L., Tempel, W., Frye, S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3OO:3-BROMO-N-[3-(TERT-BUTYLAMINO)PROPYL]BENZAMIDE'>3OO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rg2 RCSB], [http://www.ebi.ac.uk/pdbsum/4rg2 PDBsum]</span></td></tr>
-Description: Tudor Domain of Tumor suppressor p53BP1 with small molecule ligand
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
+== Function ==
+[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H.]]
+[[Category: Bountra, C.]]
+[[Category: Brown, P J.]]
+[[Category: Dong, A.]]
+[[Category: Edwards, A M.]]
+[[Category: Frye, S.]]
+[[Category: James, L.]]
+[[Category: Mader, P.]]
+[[Category: Perfetti, M.]]
+[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Tempel, W.]]
+[[Category: 53bp1 tudor]]
+[[Category: Sgc]]
+[[Category: Structural genomic]]
+[[Category: Structural genomics consortium]]
+[[Category: Transcription]]