4u32: Difference between revisions
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''' | ==Human mesotrypsin complexed with HAI-2 Kunitz domain 1== | ||
<StructureSection load='4u32' size='340' side='right' caption='[[4u32]], [[Resolution|resolution]] 1.65Å' scene=''> | |||
The entry | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4u32]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U32 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u30|4u30]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u32 RCSB], [http://www.ebi.ac.uk/pdbsum/4u32 PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/SPIT2_HUMAN SPIT2_HUMAN]] Congenital sodium diarrhea. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SPIT2_HUMAN SPIT2_HUMAN]] Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. [[http://www.uniprot.org/uniprot/TRY3_HUMAN TRY3_HUMAN]] Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.<ref>PMID:12021776</ref> <ref>PMID:14507909</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Trypsin]] | |||
[[Category: Radisky, E S.]] | |||
[[Category: Soares, A S.]] | |||
[[Category: Wang, R.]] | |||
[[Category: Enzyme kinetic]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Protease inhibitor]] | |||
[[Category: Protein degradation]] | |||
[[Category: Protein-protein interaction]] | |||
[[Category: Proteolysis]] | |||
[[Category: Serine protease]] | |||
[[Category: Substrate specificity]] | |||
Revision as of 11:04, 20 October 2014
Human mesotrypsin complexed with HAI-2 Kunitz domain 1
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