2l37: Difference between revisions

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[[Image:2l37.png|left|200px]]
==3D solution structure of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrical)==
<StructureSection load='2l37' size='340' side='right' caption='[[2l37]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2l37]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Luffa_aegyptiaca Luffa aegyptiaca]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L37 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L37 FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l37 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l37 RCSB], [http://www.ebi.ac.uk/pdbsum/2l37 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Luffin P1, the smallest ribosome-inactivating peptide from the seeds of Luffa cylindrica was found to have anti-HIV-1 activity in HIV-1 infected C8166 T-cell lines and be able to bind with HIV Rev Response Element. Nuclear magnetic resonance spectroscopy revealed that the Luffin P1 comprises a helix-loop-helix motif, with the two alpha helices tightly associated by two disulfide bonds. Based on our findings, we conclude that unlike the well-studied ribosome-inactivating proteins, which exert their action through N-glycosidase activities, Luffin P1 demonstrates a novel inactivation mechanism probably through the charge complementation with viral or cellular proteins. Our work also provides a new scaffold for the design of novel inhibitors from a simple helical motif.


{{STRUCTURE_2l37|  PDB=2l37  |  SCENE=  }}
Structural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrica).,Ng YM, Yang Y, Sze KH, Zhang X, Zheng YT, Shaw PC J Struct Biol. 2010 Dec 31. PMID:21195767<ref>PMID:21195767</ref>


===3D solution structure of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrical)===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_21195767}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[2l37]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Luffa_aegyptiaca Luffa aegyptiaca]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L37 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:021195767</ref><references group="xtra"/>
[[Category: Luffa aegyptiaca]]
[[Category: Luffa aegyptiaca]]
[[Category: RRNA N-glycosylase]]
[[Category: RRNA N-glycosylase]]
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