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[[Image:2rf3.png|left|200px]]
==Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles==
<StructureSection load='2rf3' size='340' side='right' caption='[[2rf3]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2rf3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RF3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TCY:(2R,3AS,4AR,5AR,5BS)-2-(6-AMINO-9H-PURIN-9-YL)-3A-HYDROXYHEXAHYDROCYCLOPROPA[4,5]CYCLOPENTA[1,2-B]FURAN-5A(4H)-YL+DIHYDROGEN+PHOSPHATE'>TCY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rf3 RCSB], [http://www.ebi.ac.uk/pdbsum/2rf3 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.


{{STRUCTURE_2rf3|  PDB=2rf3  |  SCENE=  }}
Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles.,Pallan PS, Ittig D, Heroux A, Wawrzak Z, Leumann CJ, Egli M Chem Commun (Camb). 2008 Feb 21;(7):883-5. Epub 2007 Dec 21. PMID:18253536<ref>PMID:18253536</ref>


===Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_18253536}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[2rf3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF3 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:018253536</ref><references group="xtra"/>
[[Category: Egli, M.]]
[[Category: Egli, M.]]
[[Category: Heroux, A.]]
[[Category: Heroux, A.]]
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