4r6v: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

==Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations==

~~The entry 4r6v is ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4r6v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R6V OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R6V FirstGlance].

~~Authors: Huang, Z., Mohammadi, M.~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=FI3:N-[4-({[(2,6-DICHLORO-3,5-DIMETHOXYPHENYL)CARBAMOYL](6-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO}METHYL)PHENYL]PROPANAMIDE'>FI3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

~~Description:~~ Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r6v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r6v RCSB], [http://www.ebi.ac.uk/pdbsum/4r6v PDBsum]</td></tr>

</table>

__TOC__

</StructureSection>

[[Category: Receptor protein-tyrosine kinase]]

[[Category: Huang, Z.]]

[[Category: Mohammadi, M.]]

[[Category: Cell signaling]]

[[Category: Kinase domain fold]]

[[Category: Phosphotransferase]]

[[Category: Plasmamembrane]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations==
+<StructureSection load='4r6v' size='340' side='right' caption='[[4r6v]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-The entry 4r6v is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4r6v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R6V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R6V FirstGlance]. <br>
-Authors: Huang, Z., Mohammadi, M.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FI3:N-[4-({[(2,6-DICHLORO-3,5-DIMETHOXYPHENYL)CARBAMOYL](6-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO}METHYL)PHENYL]PROPANAMIDE'>FI3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qq5|4qq5]], [[4qqc|4qqc]], [[4qqt|4qqt]], [[4qrc|4qrc]], [[4qqj|4qqj]]</td></tr>
-Description: Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r6v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r6v RCSB], [http://www.ebi.ac.uk/pdbsum/4r6v PDBsum]</span></td></tr>
+</table>
+__TOC__
+</StructureSection>
+[[Category: Receptor protein-tyrosine kinase]]
+[[Category: Huang, Z.]]
+[[Category: Mohammadi, M.]]
+[[Category: Cell signaling]]
+[[Category: Kinase domain fold]]
+[[Category: Phosphotransferase]]
+[[Category: Plasmamembrane]]
+[[Category: Transferase-transferase inhibitor complex]]