2yps: Difference between revisions
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''' | ==Crystal structure of the PX domain of human sorting nexin 3== | ||
<StructureSection load='2yps' size='340' side='right' caption='[[2yps]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2yps]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YPS FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yps RCSB], [http://www.ebi.ac.uk/pdbsum/2yps PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN]] MMEP syndrome. The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving SNX3 has been found in patients with syndromic microphthalmia. Translocation t(6;13)(q21;q12). | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN]] Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation.<ref>PMID:11433298</ref> <ref>PMID:18767904</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arrowsmith, C H.]] | |||
[[Category: Bountra, C.]] | |||
[[Category: Canning, P.]] | |||
[[Category: Delft, F von.]] | |||
[[Category: Edwards, A M.]] | |||
[[Category: Froese, D S.]] | |||
[[Category: Kiyani, W.]] | |||
[[Category: Krojer, T.]] | |||
[[Category: Strain-Damerell, C.]] | |||
[[Category: Yue, W W.]] | |||
[[Category: Endosome]] | |||
[[Category: Protein transport]] | |||
Revision as of 11:50, 29 October 2014
Crystal structure of the PX domain of human sorting nexin 3
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