365d: Difference between revisions
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[[ | ==STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE== | ||
<StructureSection load='365d' size='340' side='right' caption='[[365d]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[365d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=365D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=365D FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IIP:IMIDAZOLE-PYRROLE+POLYAMIDE'>IIP</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=365d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=365d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=365d RCSB], [http://www.ebi.ac.uk/pdbsum/365d PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Small molecules that target specific DNA sequences offer a potentially general approach for the regulation of gene expression. Pyrrole-imidazole polyamides represent the only class of synthetic small molecules that can bind predetermined DNA sequences with affinities and specificities comparable to DNA binding proteins. Antiparallel side-by-side pairings of two aromatic amino acids, imidazole (Im) and pyrrole (Py), distinguish G.C from C.G, and both from A.T/T.A base pairs. A high resolution X-ray crystal structure of a four-ring pyrrole-imidazole polyamide specifically bound as a dimer to a six-base pair predetermined DNA site reveals a structural framework of hydrogen bonds and interactions with the walls of the minor groove that underlies the pairing rules for DNA recognition. | |||
Structural basis for G.C recognition in the DNA minor groove.,Kielkopf CL, Baird EE, Dervan PB, Rees DC Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:9461074<ref>PMID:9461074</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Baird, E E.]] | [[Category: Baird, E E.]] | ||
[[Category: Dervan, P B.]] | [[Category: Dervan, P B.]] | ||
Revision as of 11:55, 29 October 2014
STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE
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