4o0a: Difference between revisions

Line 1:

~~{{STRUCTURE_4o0a| PDB=4o0a | SCENE= }}~~

==Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions==

===Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions===

== Structural highlights ==

<table><tr><td colspan='2'>[[4o0a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O0A OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O0A FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=2P9:5-{4-[({[4-(5-CARBOXYFURAN-2-YL)-2-CHLOROPHENYL]CARBONOTHIOYL}AMINO)METHYL]PHENYL}-1-(3,4-DICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC+ACID'>2P9</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o0a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o0a RCSB], [http://www.ebi.ac.uk/pdbsum/4o0a PDBsum]</td></tr>

</table>

==~~Function~~==

==See Also==

[[http://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN]] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA ~~intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication~~ protein ~~A complex (aRPA). aRPA binds single~~-stranded DNA ~~and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S~~-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>

*[[Single-stranded DNA-binding protein|Single-stranded DNA-binding protein]]

__TOC__

~~==About this Structure==~~

</StructureSection>

~~[[4o0a~~]] ~~is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O0A OCA].~~

~~==Reference==~~

~~<references group="xtra"/>~~<~~references~~/>

[[Category: Camper, D V.]]

[[Category: Chazin, W J.]]

[[Category: Feldkamp, M D.]]

[[Category: Fesik, S W.]]

[[Category: Frank, A O]]

[[Category: Frank, A O.]]

[[Category: Kennedy, J P.]]

[[Category: Olejniczak, E T.]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-{{STRUCTURE_4o0a|  PDB=4o0a  |  SCENE=  }}
+==Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions==
-===Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions===
+<StructureSection load='4o0a' size='340' side='right' caption='[[4o0a]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4o0a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O0A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O0A FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2P9:5-{4-[({[4-(5-CARBOXYFURAN-2-YL)-2-CHLOROPHENYL]CARBONOTHIOYL}AMINO)METHYL]PHENYL}-1-(3,4-DICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC+ACID'>2P9</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4luv|4luv]], [[4lwc|4lwc]], [[4lwi|4lwi]], [[4luz|4luz]], [[4luo|4luo]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o0a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o0a RCSB], [http://www.ebi.ac.uk/pdbsum/4o0a PDBsum]</span></td></tr>
+</table>
-==Function==
+==See Also==
-[[http://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN]] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>   Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
+*[[Single-stranded DNA-binding protein|Single-stranded DNA-binding protein]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[4o0a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O0A OCA].
-==Reference==
-<references group="xtra"/><references/>
 [[Category: Camper, D V.]]
 [[Category: Chazin, W J.]]
 [[Category: Feldkamp, M D.]]
 [[Category: Fesik, S W.]]
-[[Category: Frank, A O]]
+[[Category: Frank, A O.]]
 [[Category: Kennedy, J P.]]
 [[Category: Olejniczak, E T.]]