4uos: Difference between revisions

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'''Unreleased structure'''
==Thermodynamic hyperstability in parametrically designed helical bundles==
<StructureSection load='4uos' size='340' side='right' caption='[[4uos]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4uos]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UOS FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uot|4uot]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uos RCSB], [http://www.ebi.ac.uk/pdbsum/4uos PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We describe a procedure for designing proteins with backbones produced by varying the parameters in the Crick coiled coil-generating equations. Combinatorial design calculations identify low-energy sequences for alternative helix supercoil arrangements, and the helices in the lowest-energy arrangements are connected by loop building. We design an antiparallel monomeric untwisted three-helix bundle with 80-residue helices, an antiparallel monomeric right-handed four-helix bundle, and a pentameric parallel left-handed five-helix bundle. The designed proteins are extremely stable (extrapolated DeltaGfold &gt; 60 kilocalories per mole), and their crystal structures are close to those of the design models with nearly identical core packing between the helices. The approach enables the custom design of hyperstable proteins with fine-tuned geometries for a wide range of applications.


The entry 4uos is ON HOLD  until Paper Publication
High thermodynamic stability of parametrically designed helical bundles.,Huang PS, Oberdorfer G, Xu C, Pei XY, Nannenga BL, Rogers JM, DiMaio F, Gonen T, Luisi B, Baker D Science. 2014 Oct 24;346(6208):481-5. doi: 10.1126/science.1257481. PMID:25342806<ref>PMID:25342806</ref>


Authors: Oberdorfer, G., Huang, P., Pei, X.Y., Xu, C., Gonen, T., Nannenga, B., DiMaio, D., Rogers, J., Luisi, B.F., Baker, D.
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
Description: Thermodynamic hyperstability in parametrically designed helical bundles
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Baker, D.]]
[[Category: DiMaio, D.]]
[[Category: Gonen, T.]]
[[Category: Huang, P.]]
[[Category: Luisi, B F.]]
[[Category: Nannenga, B.]]
[[Category: Oberdorfer, G.]]
[[Category: Pei, X Y.]]
[[Category: Rogers, J.]]
[[Category: Xu, C.]]
[[Category: De novo protein]]
[[Category: Protein design]]
[[Category: Thermodynamic hyperstability helical bundle]]
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