1kce: Difference between revisions

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[[Image:1kce.gif|left|200px]]~~<br /><applet load~~="1kce~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1kce.gif|left|200px]]

~~caption="~~1kce, resolution 2.00Å" />

'''E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)'''~~<br />~~

{{Structure

|PDB= 1kce |SIZE=350|CAPTION= <scene name='initialview01'>1kce</scene>, resolution 2.00Å

|SITE=

|LIGAND= <scene name='pdbligand=UMP:2'-DEOXYURIDINE+5'-MONOPHOSPHATE'>UMP</scene> and <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC ACID'>CB3</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]

|GENE= THYA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])

}}

'''E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)'''

==Overview==

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==About this Structure==

1KCE is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli~~] with <scene name='pdbligand=UMP:'>UMP</scene> and <scene name='pdbligand=CB3:'>CB3</scene> as [http://en.wikipedia.org/wiki/ligands ligands~~]. ~~Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCE OCA].

1KCE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCE OCA].

==Reference==

An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q., Sage CR, Rutenber EE, Stout TJ, Stroud RM, Biochemistry. 1996 Dec 17;35(50):16270-81. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~8973201 8973201]

An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q., Sage CR, Rutenber EE, Stout TJ, Stroud RM, Biochemistry. 1996 Dec 17;35(50):16270-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8973201 8973201]

[[Category: Escherichia coli]]

[[Category: Single protein]]

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[[Category: transferase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 13~~:32:29 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:15:28 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1kce.gif|left|200px]]<br /><applet load="1kce" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1kce.gif|left|200px]]
-caption="1kce, resolution 2.00&Aring;" />
-'''E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)'''<br />
+ {{Structure
+|PDB= 1kce |SIZE=350|CAPTION= <scene name='initialview01'>1kce</scene>, resolution 2.00&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=UMP:2'-DEOXYURIDINE+5'-MONOPHOSPHATE'>UMP</scene> and <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC ACID'>CB3</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
+|GENE= THYA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
+}}
+'''E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-KCE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=UMP:'>UMP</scene> and <scene name='pdbligand=CB3:'>CB3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCE OCA].
+KCE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCE OCA].
 ==Reference==
-An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q., Sage CR, Rutenber EE, Stout TJ, Stroud RM, Biochemistry. 1996 Dec 17;35(50):16270-81. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8973201 8973201]
+An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q., Sage CR, Rutenber EE, Stout TJ, Stroud RM, Biochemistry. 1996 Dec 17;35(50):16270-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8973201 8973201]
 [[Category: Escherichia coli]]
 [[Category: Single protein]]
@@ Line 23: / Line 32: @@
 [[Category: transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:32:29 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:15:28 2008''