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{{STRUCTURE_3loc|  PDB=3loc  |  SCENE=  }}
==Crystal structure of putative transcriptional regulator ycdc==
===Crystal structure of putative transcriptional regulator ycdc===
<StructureSection load='3loc' size='340' side='right' caption='[[3loc]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3loc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1pb6 1pb6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LOC FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/RUTR_ECOLI RUTR_ECOLI]] Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX).<ref>PMID:16540542</ref> <ref>PMID:17919280</ref>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=URA:URACIL'>URA</scene></td></tr>
 
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
==About this Structure==
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b1013, JW0998, rutR, ycdC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
[[3loc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1pb6 1pb6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOC OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3loc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3loc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3loc RCSB], [http://www.ebi.ac.uk/pdbsum/3loc PDBsum]</span></td></tr>
 
</table>
==Reference==
== Evolutionary Conservation ==
<references group="xtra"/><references/>
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/3loc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Almo, S C.]]
[[Category: Almo, S C]]
[[Category: Burley, S K.]]
[[Category: Burley, S K]]
[[Category: Knapik, A A.]]
[[Category: Knapik, A A]]
[[Category: Mennella, V.]]
[[Category: Mennella, V]]
[[Category: Minor, W.]]
[[Category: Minor, W]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
[[Category: Structural genomic]]
[[Category: Patskovsky, Y V.]]
[[Category: Patskovsky, Y V]]
[[Category: Dimer]]
[[Category: Dimer]]
[[Category: Dna-binding]]
[[Category: Dna-binding]]
[[Category: Helix-turn-helix]]
[[Category: Helix-turn-helix]]
[[Category: New york sgx research center for structural genomic]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
[[Category: Nysgxrc]]
[[Category: PSI, Protein structure initiative]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Putative transcriptional regulator]]
[[Category: Putative transcriptional regulator]]
[[Category: Repressor]]
[[Category: Repressor]]
[[Category: Structural genomic]]
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Uracil]]
[[Category: Uracil]]

Revision as of 12:53, 6 November 2014

Crystal structure of putative transcriptional regulator ycdc

3loc, resolution 2.50Å

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