1ki3: Difference between revisions

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[[Image:1ki3.gif|left|200px]]<br /><applet load="1ki3" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ki3.gif|left|200px]]
caption="1ki3, resolution 2.37&Aring;" />
 
'''CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH PENCICLOVIR'''<br />
{{Structure
|PDB= 1ki3 |SIZE=350|CAPTION= <scene name='initialview01'>1ki3</scene>, resolution 2.37&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=PE2:9-(4-HYDROXY-3-(HYDROXYMETHYL)BUT-1-YL)GUANINE'>PE2</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21]
|GENE= TK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10376 Human herpesvirus 4])
}}
 
'''CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH PENCICLOVIR'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1KI3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=PE2:'>PE2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI3 OCA].  
1KI3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI3 OCA].  


==Reference==
==Reference==
Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands., Champness JN, Bennett MS, Wien F, Visse R, Summers WC, Herdewijn P, de Clerq E, Ostrowski T, Jarvest RL, Sanderson MR, Proteins. 1998 Aug 15;32(3):350-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9715911 9715911]
Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands., Champness JN, Bennett MS, Wien F, Visse R, Summers WC, Herdewijn P, de Clerq E, Ostrowski T, Jarvest RL, Sanderson MR, Proteins. 1998 Aug 15;32(3):350-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9715911 9715911]
[[Category: Human herpesvirus 4]]
[[Category: Human herpesvirus 4]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: alphaherpesvirinae]]
[[Category: alphaherpesvirinae]]
[[Category: antiviral drug penciclovir]]
[[Category: antiviral drug penciclovir]]
[[Category: ds-dna enveloped viruses]]
[[Category: ds-dna enveloped viruse]]
[[Category: herpesviridae]]
[[Category: herpesviridae]]
[[Category: phosphotransferase]]
[[Category: phosphotransferase]]
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[[Category: viridae]]
[[Category: viridae]]


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