1klk: Difference between revisions

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[[Image:1klk.gif|left|200px]]<br /><applet load="1klk" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1klk.gif|left|200px]]
caption="1klk, resolution 2.3&Aring;" />
 
'''CRYSTAL STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH PT653 AND NADPH'''<br />
{{Structure
|PDB= 1klk |SIZE=350|CAPTION= <scene name='initialview01'>1klk</scene>, resolution 2.3&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PMD:[N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE'>PMD</scene> and <scene name='pdbligand=NDP:NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE'>NDP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH PT653 AND NADPH'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1KLK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=PMD:'>PMD</scene> and <scene name='pdbligand=NDP:'>NDP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLK OCA].  
1KLK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLK OCA].  


==Reference==
==Reference==
Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH., Cody V, Galitsky N, Luft JR, Pangborn W, Rosowsky A, Queener SF, Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):946-54. Epub, 2002 May 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12037296 12037296]
Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH., Cody V, Galitsky N, Luft JR, Pangborn W, Rosowsky A, Queener SF, Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):946-54. Epub, 2002 May 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12037296 12037296]
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: NDP]]
[[Category: NDP]]
[[Category: PMD]]
[[Category: PMD]]
[[Category: aids]]
[[Category: aid]]
[[Category: antifolate]]
[[Category: antifolate]]
[[Category: protein-inhibitor complex]]
[[Category: protein-inhibitor complex]]
[[Category: structure-based design]]
[[Category: structure-based design]]


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