1kw0: Difference between revisions

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[[Image:1kw0.gif|left|200px]]<br /><applet load="1kw0" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1kw0.gif|left|200px]]
caption="1kw0, resolution 2.50&Aring;" />
 
'''Catalytic Domain of Human Phenylalanine Hydroxylase (Fe(II)) in Complex with Tetrahydrobiopterin and Thienylalanine'''<br />
{{Structure
|PDB= 1kw0 |SIZE=350|CAPTION= <scene name='initialview01'>1kw0</scene>, resolution 2.50&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene> and <scene name='pdbligand=TIH:BETA(2-THIENYL)ALANINE'>TIH</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1]
|GENE= PAH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Catalytic Domain of Human Phenylalanine Hydroxylase (Fe(II)) in Complex with Tetrahydrobiopterin and Thienylalanine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1KW0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FE2:'>FE2</scene>, <scene name='pdbligand=H4B:'>H4B</scene> and <scene name='pdbligand=TIH:'>TIH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW0 OCA].  
1KW0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW0 OCA].  


==Reference==
==Reference==
Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its implications for the mechanism of catalysis and substrate activation., Andersen OA, Flatmark T, Hough E, J Mol Biol. 2002 Jul 26;320(5):1095-108. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12126628 12126628]
Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its implications for the mechanism of catalysis and substrate activation., Andersen OA, Flatmark T, Hough E, J Mol Biol. 2002 Jul 26;320(5):1095-108. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12126628 12126628]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phenylalanine 4-monooxygenase]]
[[Category: Phenylalanine 4-monooxygenase]]
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[[Category: H4B]]
[[Category: H4B]]
[[Category: TIH]]
[[Category: TIH]]
[[Category: basket-arrangement 13 alpha-helices and 6 beta-strands]]
[[Category: basket-arrangement 13 alpha-helices and 6 beta-strand]]
[[Category: ferrous iron]]
[[Category: ferrous iron]]


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