3d6r: Difference between revisions
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[[ | ==Structure of an avian influenza A virus NS1 protein effector domain== | ||
<StructureSection load='3d6r' size='340' side='right' caption='[[3d6r]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3d6r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D6R FirstGlance]. <br> | |||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11320 Influenza A virus])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d6r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d6r RCSB], [http://www.ebi.ac.uk/pdbsum/3d6r PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Influenza A virus NS1 protein is a multifunctional virulence factor. Here, we report a crystal structure for the NS1 effector domain of avian influenza virus A/Duck/Albany/76. Comparison of this structure with that reported for a human strain shows both proteins share a common monomer conformation, albeit with subtle differences. Strikingly, our data reveal a novel helix-helix dimeric interface between monomers of the avian NS1 protein, which is also found in the human NS1 crystal lattice. We re-evaluate the current model of NS1 dimeric assembly, and provide biochemical evidence to show tryptophan-187 (a residue located at the helix-helix interface) is essential for dimerization of this effector domain. | |||
Structure of an avian influenza A virus NS1 protein effector domain.,Hale BG, Barclay WS, Randall RE, Russell RJ Virology. 2008 Aug 15;378(1):1-5. Epub 2008 Jun 27. PMID:18585749<ref>PMID:18585749</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Influenza a virus]] | [[Category: Influenza a virus]] | ||
[[Category: Barclay, W S | [[Category: Barclay, W S]] | ||
[[Category: Hale, B G | [[Category: Hale, B G]] | ||
[[Category: Randall, R E | [[Category: Randall, R E]] | ||
[[Category: Russell, R J | [[Category: Russell, R J]] | ||
[[Category: Effector domain]] | [[Category: Effector domain]] | ||
[[Category: Host-virus interaction]] | [[Category: Host-virus interaction]] | ||
Revision as of 08:03, 12 November 2014
Structure of an avian influenza A virus NS1 protein effector domain
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