1kzi: Difference between revisions

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[[Image:1kzi.gif|left|200px]]<br /><applet load="1kzi" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1kzi.gif|left|200px]]
caption="1kzi, resolution 1.75&Aring;" />
 
'''Crystal Structure of EcTS/dUMP/THF Complex'''<br />
{{Structure
|PDB= 1kzi |SIZE=350|CAPTION= <scene name='initialview01'>1kzi</scene>, resolution 1.75&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=UMP:2'-DEOXYURIDINE+5'-MONOPHOSPHATE'>UMP</scene>, <scene name='pdbligand=THG:(6S)-5,6,7,8-TETRAHYDROFOLATE'>THG</scene>, <scene name='pdbligand=DTU:(2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTU</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE=
}}
 
'''Crystal Structure of EcTS/dUMP/THF Complex'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1KZI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=CO3:'>CO3</scene>, <scene name='pdbligand=UMP:'>UMP</scene>, <scene name='pdbligand=THG:'>THG</scene>, <scene name='pdbligand=DTU:'>DTU</scene>, <scene name='pdbligand=DTT:'>DTT</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZI OCA].  
1KZI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZI OCA].  


==Reference==
==Reference==
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access., Fritz TA, Liu L, Finer-Moore JS, Stroud RM, Biochemistry. 2002 Jun 4;41(22):7021-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12033935 12033935]
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access., Fritz TA, Liu L, Finer-Moore JS, Stroud RM, Biochemistry. 2002 Jun 4;41(22):7021-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12033935 12033935]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: enzyme substrate complex]]
[[Category: enzyme substrate complex]]


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