2y38: Difference between revisions

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[[Image:2y38.png|left|200px]]
==LAMININ ALPHA5 CHAIN N-TERMINAL FRAGMENT==
<StructureSection load='2y38' size='340' side='right' caption='[[2y38]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2y38]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y38 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y38 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y38 RCSB], [http://www.ebi.ac.uk/pdbsum/2y38 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The polymerization of laminin into a cell-associated network-a key step in basement membrane assembly-is mediated by the laminin amino-terminal (LN) domains at the tips of the three short arms of the laminin alphabetagamma-heterotrimer. The crystal structure of a laminin alpha5LN-LE1-2 fragment shows that the LN domain is a beta-jelly roll with several elaborate insertions that is attached like a flower head to the stalk-like laminin-type epidermal growth factor-like tandem. A surface loop that is strictly conserved in the LN domains of all alpha-short arms is required for stable ternary association with the beta- and gamma-short arms in the laminin network.


{{STRUCTURE_2y38|  PDB=2y38  |  SCENE=  }}
Determinants of laminin polymerization revealed by the structure of the alpha5 chain amino-terminal region.,Hussain SA, Carafoli F, Hohenester E EMBO Rep. 2011 Feb 11. PMID:21311558<ref>PMID:21311558</ref>


===LAMININ ALPHA5 CHAIN N-TERMINAL FRAGMENT===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_21311558}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[2y38]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y38 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:021311558</ref><references group="xtra"/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Carafoli, F.]]
[[Category: Carafoli, F]]
[[Category: Hohenester, E.]]
[[Category: Hohenester, E]]
[[Category: Hussain, S A.]]
[[Category: Hussain, S A]]
[[Category: Basement membrane]]
[[Category: Basement membrane]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
[[Category: Structural protein]]
[[Category: Structural protein]]
Retrieved from "https://proteopedia.org/2y38"