4pqq: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pqq RCSB], [http://www.ebi.ac.uk/pdbsum/4pqq PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pqq RCSB], [http://www.ebi.ac.uk/pdbsum/4pqq PDBsum]</span></td></tr> | ||
</table> | </table> | ||
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== Publication Abstract from PubMed == | |||
Muskelin is an intracellular kelch-repeat protein comprised of discoidin, LisH, CTLH and kelch-repeat domains. It is involved in cell adhesion and the regulation of cytoskeleton dynamics as well as being a component of a putative E3 ligase complex. Here, the first crystal structure of mouse muskelin discoidin domain (MK-DD) is reported at 1.55 A resolution, which reveals a distorted eight-stranded beta-barrel with two short alpha-helices at one end of the barrel. Interestingly, the N- and C-termini are not linked by the disulfide bonds found in other eukaryotic discoidin structures. A highly conserved MIND motif appears to be the determinant for MK-DD specific interaction together with the spike loops. Analysis of interdomain interaction shows that MK-DD binds the kelch-repeat domain directly and that this interaction depends on the presence of the LisH domain. | |||
Structure of mouse muskelin discoidin domain and biochemical characterization of its self-association.,Kim KH, Hong SK, Hwang KY, Kim EE Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):2863-74. doi:, 10.1107/S139900471401894X. Epub 2014 Oct 16. PMID:25372678<ref>PMID:25372678</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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== References == | |||
<references/> | |||
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</StructureSection> | </StructureSection> | ||
Revision as of 10:30, 19 November 2014
The crystal structure of discoidin domain from muskelin
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