4v10

Skelemin Association with alfa2b,betta3 Integrin: A Structural Model

spinqualitylabelsall models 4v10, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4v10 is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Over the last two decades, our knowledge concerning intracellular events that regulate integrin's affinity to their soluble ligands has significantly improved. However, the mechanism of adhesion-induced integrin clustering and development of focal complexes, which could further mature to form focal adhesions, still remains under-investigated. Here we present a structural model of tandem IgC2 domains of skelemin in complex with the cytoplasmic tails of integrin alphaIIbbeta3. The model is generated based upon NMR data and this tertiary assembly illuminates a potential link between the essential cell adhesion receptors and myosin filaments. This connection may serve as a basis for generating the mechanical forces necessary for cell migration and remodeling. Skelemin Association with AlphaIIbBeta3 Integrin: A Structural Model.,Gorbatyuk V, Nguyen K, Podolnikova NP, Deshmukh L, Lin X, Ugarova TP, Vinogradova O Biochemistry. 2014 Sep 15. PMID:25224262 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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