Calmodulin: Difference between revisions

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{{STRUCTURE_1prw|  PDB=1prw  | SIZE=400| SCENE=Calmodulin/Cv/2 |right|CAPTION=Bovine calmodulin showing Ca+2 with trimethyl lysine, [[1prw]] }}
{{STRUCTURE_1prw|  PDB=1prw  | SIZE=400| SCENE=Calmodulin/Cv/2 |right|CAPTION=Bovine calmodulin showing Ca+2 with trimethyl lysine, [[1prw]] }}


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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


=== Native CaM ===
* Native CaM  
 
[[1prw]], [[1deg]] – bCaM - bovine<br />
[[1up5]] – cCaM – chicken<br />
[[1clm]], [[1osa]], [[1exr]] – PtCaM - ''Paramecium tetraurelia''<br />
[[3cln]] – rCaM - rat<br />
[[1x02]], [[1dmo]] – XlCaM – NMR - ''Xenopus laevis''<br />
[[2k61]], [[2k0e]] – hCaM – NMR - human<br />
[[1y6w]], [[1cll]], [[4bw8]] - hCaM<br />
[[4cln]] – DmCaM - ''Drosophila melanogaster''<br />
[[1rfj]] – CaM – potato<br />
[[1ooj]] – CaM – ''Caenorhabditis elegans''<br />
[[4hex]] – mCaM – mouse<br />


=== Mutant CaM ===
**[[1prw]], [[1deg]] – bCaM - bovine<br />
**[[1up5]] – cCaM – chicken<br />
**[[1clm]], [[1osa]], [[1exr]] – PtCaM - ''Paramecium tetraurelia''<br />
**[[3cln]] – rCaM - rat<br />
**[[1x02]], [[1dmo]] – XlCaM – NMR - ''Xenopus laevis''<br />
**[[2k61]], [[2k0e]] – hCaM – NMR - human<br />
**[[1y6w]], [[1cll]], [[4bw8]] - hCaM<br />
**[[4cln]] – DmCaM - ''Drosophila melanogaster''<br />
**[[1rfj]] – CaM – potato<br />
**[[1ooj]] – CaM – ''Caenorhabditis elegans''<br />
**[[4hex]] – mCaM – mouse<br />


[[1ahr]], [[2m3s]] – cCaM (mutant)<br />
* Mutant CaM
[[2k0j]], [[1sw8]] – hCaM (mutant) – NMR<br />


=== apo CaM ===
**[[1ahr]], [[2m3s]] – cCaM (mutant)<br />
**[[2k0j]], [[1sw8]] – hCaM (mutant) – NMR<br />


[[1lkj]] – yapoCaM – NMR -yeast<br />
* apo CaM
[[1cfc]], [[1cfd]] - XlapoCaM – NMR<br />
[[1qx5]] – rapoCaM – rat<br />


=== CaM N-terminal ===
**[[1lkj]] – yapoCaM – NMR -yeast<br />
**[[1cfc]], [[1cfd]] - XlapoCaM – NMR<br />
**[[1qx5]] – rapoCaM – rat<br />


[[2i08]] - hCaM N-terminal (mutant)<br />
* CaM N-terminal  
[[1j7o]], [[1j7p]] - hCaM N-terminal – NMR<br />
[[1f70]] - XlCaM N-terminal – NMR <br />
[[2ro8]], [[2roa]] - sCaM N-terminal+Ca – NMR - soybean<br />
[[2ro9]], [[2rob]] - sCaM C-terminal+Ca – NMR<br />
[[3ifk]], [[3b32]] – rCaM N-terminal <br />
[[1f54]], [[1f55]] – yapoCaM N-terminal – NMR<br />


=== CaM C-terminal ===
**[[2i08]] - hCaM N-terminal (mutant)<br />
**[[1j7o]], [[1j7p]] - hCaM N-terminal – NMR<br />
**[[1f70]] - XlCaM N-terminal – NMR <br />
**[[2ro8]], [[2roa]] - sCaM N-terminal+Ca – NMR - soybean<br />
**[[2ro9]], [[2rob]] - sCaM C-terminal+Ca – NMR<br />
**[[3ifk]], [[3b32]] – rCaM N-terminal <br />
**[[1f54]], [[1f55]] – yapoCaM N-terminal – NMR<br />


[[1f71]] - XlCaM C-terminal – NMR<br />
* CaM C-terminal  
[[1cmg]] – bCaM C-terminal – NMR<br />
[[1fw4]] - bCaM C-terminal<br />
[[1cmf]] – bapoCaM C-terminal – NMR<br />
[[2hf5]] - hCaM EF2 EF3 – NMR<br />
[[2lqp]] - hCaM EF3 EF4 – NMR<br />
[[2kxw]] – PtapoCaM + IQ motif of NAV1.2 – NMR<br />
[[2kz2]] – CaM (mutant) – chicken<br >
[[2rrt]] – XlCaM (mutant)


=== CaM+ cations (not calcium) ===
**[[1f71]] - XlCaM C-terminal – NMR<br />
**[[1cmg]] – bCaM C-terminal – NMR<br />
**[[1fw4]] - bCaM C-terminal<br />
**[[1cmf]] – bapoCaM C-terminal – NMR<br />
**[[2hf5]] - hCaM EF2 EF3 – NMR<br />
**[[2lqp]] - hCaM EF3 EF4 – NMR<br />
**[[2kxw]] – PtapoCaM + IQ motif of NAV1.2 – NMR<br />
**[[2kz2]] – CaM (mutant) – chicken<br >
**[[2rrt]] – XlCaM (mutant)


[[2ksz]] – sCaM N-terminal+Mg – NMR <br />
* CaM+ cations (non calcium)
[[1ak8]] - bCaM N-terminal+Ce – NMR<br />
[[2eqc]] – XlCaM C-terminal+Mg– NMR<br />
[[2pq3]] – rCaM+Zn<br />
[[2v01]] – hCaM+Pb<br />
[[2v02]] – hCaM+Ba<br />
[[4bw7]] – hCaM + Sr<br />
[[3uct]] – hCaM + Mn + Zn<br />
[[3ucw]] - hCaM N-terminal + Mg<br />
[[3ucy]] - hCaM N-terminal + Mg + Zn<br />
[[1n0y]] – PtCaM+Pb <br />
[[2lhh]] – yCaM + Ca - NMR


=== CaM small molecule complexes ===
**[[2ksz]] – sCaM N-terminal+Mg – NMR <br />
**[[1ak8]] - bCaM N-terminal+Ce – NMR<br />
**[[2eqc]] – XlCaM C-terminal+Mg– NMR<br />
**[[2pq3]] – rCaM+Zn<br />
**[[2v01]] – hCaM+Pb<br />
**[[2v02]] – hCaM+Ba<br />
**[[4bw7]] – hCaM + Sr<br />
**[[3uct]] – hCaM + Mn + Zn<br />
**[[3ucw]] - hCaM N-terminal + Mg<br />
**[[3ucy]] - hCaM N-terminal + Mg + Zn<br />
**[[1n0y]] – PtCaM+Pb <br />
**[[2lhh]] – yCaM + Ca - NMR


[[3if7]] – bCaM+sphingosylphosphorylcholine<br />
* CaM small molecule complexes
[[1qiv]], [[1qiw]] – bCaM+DPDv<br />
[[1a29]], [[1lin]] – bCaM+trifluoperazine<br />
[[1ctr]] - hCaM+trifluoperazine <br />
[[2kug]], [[2kuh]] - hCaM N-terminal EF1 EF2+halothane – NMR<br />
[[2kdu]] – XlCaM+MUNC13-1 – NMR<br />
[[1mux]] – XlCaM+W-7 – NMR<br />
[[1xa5]] – bCaM+KAR-2<br />


=== CaM complexed with protein CBD domains ===
**[[3if7]] – bCaM+sphingosylphosphorylcholine<br />
**[[1qiv]], [[1qiw]] – bCaM+DPDv<br />
**[[1a29]], [[1lin]] – bCaM+trifluoperazine<br />
**[[1ctr]] - hCaM+trifluoperazine <br />
**[[2kug]], [[2kuh]] - hCaM N-terminal EF1 EF2+halothane – NMR<br />
**[[2kdu]] – XlCaM+MUNC13-1 – NMR<br />
**[[1mux]] – XlCaM+W-7 – NMR<br />
**[[1xa5]] – bCaM+KAR-2<br />


[[3gp2]] – cCaM+CaM kinase II δ chain<br />
* CaM complexed with protein CBD domains
[[2dfs]] – cCaM+myosin 5A<br />
[[2o5g]] – cCaM+ myosin light chain kinase peptide<br />
[[2bcx]] – cCaM+ryanodine receptor 1 peptide<br />
[[3gof]], [[2o60]] – cCaM+nitric oxide synthase  CBD<br />
[[1niw]] - rCaM+nitric oxide synthase  CBD <br />
[[2hqw]] - rCaM+glutamate receptor peptide<br />
[[3bxk]], [[3bxl]], [[4ehq]], [[4j9y]], [[4j9z]] – rCaM+ calcium channel peptide<br />
[[1g4y]], [[3sjq]], [[4g27]], [[4g28]] - rCaM+ potassium channel CBD<br />
[[2ygg]] – rCaM + Na/H exchanger CBD<br />
[[2mgu]] – rCaM + HIV-1 matrix protein CBD – NMR<br />
[[1qx7]] – rapoCaM+potassium channel peptide<br />
[[4gow]] – hCaM + potassium channel peptide<br />
[[3hr4]], [[2ll6]], [[2ll7]] - hCaM+nitric oxide synthase  CBD <br />
[[1yr5]], [[1wrz]], [[2y4v]] – hCaM+death-associated protein kinase 1 (DAP)<br />
[[2l7l]] - hCaM+ CaM-dependent protein kinase 1 CBD<br />
[[2m0j]], [[2m0k]] - hCaM+olfactory channel peptide<br />
[[2kne]] – hCaM+PMCA C-terminal CBD<br />
[[3ewt]], [[3ewv]] – hCaM+TNFR fragment<br />
[[2w73]], [[2jzi]], [[2r28]] – hCaM+Ser/Thr phosphatase CBD<br />
[[3bya]] – hCaM+glutamate receptor peptide<br />
[[3g43]], [[2vay]], [[2f3y]], [[2f3z]], [[2be6]], [[2lqc]], [[3oxq]] – hCaM+calcium channel CAV1.2<br />
[[3dve]], [[3dvj]], [[3dvk]], [[3dvm]] - hCaM+calcium channel CAV2.2<br />
[[2k0f]], [[2lv6]] – hCaM+myosin light chain kinase peptide – NMR<br />
[[1zuz]] – hCaM+DRP kinase peptide<br />
[[1l7z]] – hCaM+CAP-23/NAP-22 CBD<br />
[[1cdl]] - hCaM+CaM dependent kinase CBD<br />
[[1iwq]] - hCaM+MARCKS CBD<br />
[[3sui]] – hCaM + capsaicin receptor peptide<br />
[[2m55]] – hCaM + α-synuclein peptide<br />
[[2kn2]] – sCaM C-terminal+NtMKP1 CBD – NMR<br />
[[1cff]] - XlCaM+ calcium channel CBD - NMR<br />
[[1sy9]] – XlCaM+olfactory channel peptide<br />
[[1nwd]] – XlCaM+glutamate decarboxylase CBD<br />
[[1iq5]] – XlCaM+CaM dependent kinase CBD<br />
[[1ckk]] - XlCaM+CaM dependent kinase CBD - NMR<br />
[[2llo]], [[2llq]] – XlCaM EF-hand domain + estrogen receptor CBD – NMR<br />
[[2bbm]], [[2bbn]] - DmCaM+myosin light chain kinase peptide<br />
[[1mxe]] – DmCaM+rCaMKI CBD <br />
[[2fot]] - bCaM+α-II spectrin CBD<br />
[[2f2o]], [[2f2p]] – bCaM+calcium<br />
[[1xa5]] – bCaM+KAR-2<br />
[[1cm1]], [[1cm4]], [[1cdm]] - bCaM+CaM dependent kinase CBD<br />
[[4e50]] – mCam/linker/neurogranin IQ motif <br />
[[4e53]] – mCam/linker/neuromoduin IQ motif <br />
[[1aqr]] – CaM-7 + calcium-transporting ATPase peptide – ''Arabidopsis thaliana''<br />


'''Calmodulin complex with protein'''
**[[3gp2]] – cCaM+CaM kinase II δ chain<br />
**[[2dfs]] – cCaM+myosin 5A<br />
**[[2o5g]] – cCaM+ myosin light chain kinase peptide<br />
**[[2bcx]] – cCaM+ryanodine receptor 1 peptide<br />
**[[3gof]], [[2o60]] – cCaM+nitric oxide synthase  CBD<br />
**[[1niw]] - rCaM+nitric oxide synthase  CBD <br />
**[[2hqw]] - rCaM+glutamate receptor peptide<br />
**[[3bxk]], [[3bxl]], [[4ehq]], [[4j9y]], [[4j9z]] – rCaM+ calcium channel peptide<br />
**[[1g4y]], [[3sjq]], [[4g27]], [[4g28]] - rCaM+ potassium channel CBD<br />
**[[2ygg]] – rCaM + Na/H exchanger CBD<br />
**[[2mgu]] – rCaM + HIV-1 matrix protein CBD – NMR<br />
**[[1qx7]] – rapoCaM+potassium channel peptide<br />
**[[4gow]] – hCaM + potassium channel peptide<br />
**[[3hr4]], [[2ll6]], [[2ll7]] - hCaM+nitric oxide synthase  CBD <br />
**[[1yr5]], [[1wrz]], [[2y4v]] – hCaM+death-associated protein kinase 1 (DAP)<br />
**[[2l7l]] - hCaM+ CaM-dependent protein kinase 1 CBD<br />
**[[2m0j]], [[2m0k]] - hCaM+olfactory channel peptide<br />
**[[2kne]] – hCaM+PMCA C-terminal CBD<br />
**[[3ewt]], [[3ewv]] – hCaM+TNFR fragment<br />
**[[2w73]], [[2jzi]], [[2r28]] – hCaM+Ser/Thr phosphatase CBD<br />
**[[3bya]] – hCaM+glutamate receptor peptide<br />
**[[3g43]], [[2vay]], [[2f3y]], [[2f3z]], [[2be6]], [[2lqc]], [[3oxq]] – hCaM+calcium channel CAV1.2<br />
**[[3dve]], [[3dvj]], [[3dvk]], [[3dvm]] - hCaM+calcium channel CAV2.2<br />
**[[2k0f]], [[2lv6]] – hCaM+myosin light chain kinase peptide – NMR<br />
**[[1zuz]] – hCaM+DRP kinase peptide<br />
**[[1l7z]] – hCaM+CAP-23/NAP-22 CBD<br />
**[[1cdl]] - hCaM+CaM dependent kinase CBD<br />
**[[1iwq]] - hCaM+MARCKS CBD<br />
**[[3sui]] – hCaM + capsaicin receptor peptide<br />
**[[2m55]] – hCaM + α-synuclein peptide<br />
**[[2kn2]] – sCaM C-terminal+NtMKP1 CBD – NMR<br />
**[[1cff]] - XlCaM+ calcium channel CBD - NMR<br />
**[[1sy9]] – XlCaM+olfactory channel peptide<br />
**[[1nwd]] – XlCaM+glutamate decarboxylase CBD<br />
**[[1iq5]] – XlCaM+CaM dependent kinase CBD<br />
**[[1ckk]] - XlCaM+CaM dependent kinase CBD - NMR<br />
**[[2llo]], [[2llq]] – XlCaM EF-hand domain + estrogen receptor CBD – NMR<br />
**[[2bbm]], [[2bbn]] - DmCaM+myosin light chain kinase peptide<br />
**[[1mxe]] – DmCaM+rCaMKI CBD <br />
**[[2fot]] - bCaM+α-II spectrin CBD<br />
**[[2f2o]], [[2f2p]] – bCaM+calcium<br />
**[[1xa5]] – bCaM+KAR-2<br />
**[[1cm1]], [[1cm4]], [[1cdm]] - bCaM+CaM dependent kinase CBD<br />
**[[4e50]] – mCam/linker/neurogranin IQ motif <br />
**[[4e53]] – mCam/linker/neuromoduin IQ motif <br />
**[[1aqr]] – CaM-7 + calcium-transporting ATPase peptide – ''Arabidopsis thaliana''<br />


[[2col]], [[1yrt]], [[1yru]] – BpCaM+adenyl cyclase – ''Bordetella pertussis''<br />
*Calmodulin complex with protein
[[1zot]] – BpCaM C-terminal+adenyl cyclase<br />
[[1xfu]], [[1xfv]], [[1xfw]], [[1xfx]], [[1xfy]], [[1xfz]], [[1y0v]], [[1sk6]], [[1pk0]], [[1lvc]], [[1k90]], [[1k93]] - CaM+adenyl cyclase – ''Bacillus anthracis''<br />
[[2l1w]] – CaM+vacuolar calcium ATPase peptide – soybean – NMR<br />
[[2lgf]] – hCaM + selectin peptide<br />
[[3j41]] – hCaM + lens fiber major intrinsic protein – Cryo EM<br />
[[1qs7]], [[1qtx]] – CaM+RS20 – ''Escherichia coli''<br />
[[1vrk]] – CaM (mutant)+RS20<br />
[[3ek4]], [[3ek7]], [[3ek8]], [[3ekh]], [[3ekj]], [[3evr]], [[3evu]], [[3evv]], [[3o77]], [[3o78]] – CaM/DFP/myosin light chain kinase<br />
[[4ds7]] – CaM + spindle pole body component 10 – ''Kluyveromyces lactis''<br />
[[2dfs]] – cCaM+myosin 5A<br />
[[4l79]] – hCaM + myosin 1B<br />
[[2x0g]] – hCaM+death-associated protein kinase 1 (DAP)<br />
[[4djc]], [[2l53]] - hCaM+ sodium channel protein type V α subunit<br />
[[4dck]] - hCaM+ sodium channel protein type V α subunit + fibroblast growth factor 13<br />
[[2x51]], [[4anj]] – DmCaM+pMyosin IV<br />
[[2k3s]] – CaM+smoothelin-like protein 1 – NMR<br />
[[2ix7]] – apoCaM+myosin-5A<br />
[[2vas]], [[2vb6]], [[3gn4]], [[3l9i]], [[4dbp]], [[4dbq]] – DmCaM+myosin VI<br />
[[2bki]], [[2bkh]] – CaM+myosin VI – pig<br />


**[[2col]], [[1yrt]], [[1yru]] – BpCaM+adenyl cyclase – ''Bordetella pertussis''<br />
**[[1zot]] – BpCaM C-terminal+adenyl cyclase<br />
**[[1xfu]], [[1xfv]], [[1xfw]], [[1xfx]], [[1xfy]], [[1xfz]], [[1y0v]], [[1sk6]], [[1pk0]], [[1lvc]], [[1k90]], [[1k93]] - CaM+adenyl cyclase – ''Bacillus anthracis''<br />
**[[2l1w]] – CaM+vacuolar calcium ATPase peptide – soybean – NMR<br />
**[[2lgf]] – hCaM + selectin peptide<br />
**[[3j41]] – hCaM + lens fiber major intrinsic protein – Cryo EM<br />
**[[1qs7]], [[1qtx]] – CaM+RS20 – ''Escherichia coli''<br />
**[[1vrk]] – CaM (mutant)+RS20<br />
**[[3ek4]], [[3ek7]], [[3ek8]], [[3ekh]], [[3ekj]], [[3evr]], [[3evu]], [[3evv]], [[3o77]], [[3o78]] – CaM/DFP/myosin light chain kinase<br />
**[[4ds7]] – CaM + spindle pole body component 10 – ''Kluyveromyces lactis''<br />
**[[2dfs]] – cCaM+myosin 5A<br />
**[[4l79]] – hCaM + myosin 1B<br />
**[[2x0g]] – hCaM+death-associated protein kinase 1 (DAP)<br />
**[[4djc]], [[2l53]] - hCaM+ sodium channel protein type V α subunit<br />
**[[4dck]] - hCaM+ sodium channel protein type V α subunit + fibroblast growth factor 13<br />
**[[2x51]], [[4anj]] – DmCaM+pMyosin IV<br />
**[[2k3s]] – CaM+smoothelin-like protein 1 – NMR<br />
**[[2ix7]] – apoCaM+myosin-5A<br />
**[[2bki]], [[2bkh]] – CaM+myosin VI – pig<br />
}}
==See Also==
==See Also==


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