4pno: Difference between revisions
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''' | ==Escherichia coli Hfq-RNA complex at 0.97 A Resolution== | ||
<StructureSection load='4pno' size='340' side='right' caption='[[4pno]], [[Resolution|resolution]] 0.97Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4pno]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNO FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pno OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pno RCSB], [http://www.ebi.ac.uk/pdbsum/4pno PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
In bacteria, small RNAs (sRNAs) silence or activate target genes through base pairing with the mRNA, thereby modulating its translation. A central player in this process is the RNA chaperone Hfq, which facilitates the annealing of sRNAs with their target mRNAs. Hfq has two RNA-binding surfaces that recognize A-rich and U-rich sequences, and is believed to bind an sRNA-mRNA pair simultaneously. However, how Hfq promotes annealing remains unclear. Here, the crystal structure of Escherichia coli Hfq is presented in complex with U6-RNA bound to its proximal binding site at 0.97 A resolution, revealing the Hfq-RNA interaction in exceptional detail. | |||
Structure of an Escherichia coli Hfq:RNA complex at 0.97 A resolution.,Schulz EC, Barabas O Acta Crystallogr F Struct Biol Commun. 2014 Nov;70(Pt 11):1492-7. doi:, 10.1107/S2053230X14020044. Epub 2014 Oct 31. PMID:25372815<ref>PMID:25372815</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Barabas, O]] | |||
[[Category: Schulz, E C]] | |||
[[Category: Rna binding protein]] | |||
[[Category: Rna chaperone hfq rna lsm]] | |||
Revision as of 12:43, 19 November 2014
Escherichia coli Hfq-RNA complex at 0.97 A Resolution
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