4nua: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates==

~~The entry~~ 4nua is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4nua]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUA OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NUA FirstGlance].

~~Authors~~: ~~Tsoumpra~~, M.K., ~~Barnett~~, B.L., ~~Muniz, J~~.R.C., ~~Walter~~, ~~R.L.~~, Ebetino, F.H., ~~Von Delft, F~~., Russell, R.G.G., ~~Oppermann~~, ~~U., Dunford, J.E.~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr>

~~Description~~: ~~The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nua OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nua RCSB], [http://www.ebi.ac.uk/pdbsum/4nua PDBsum]</td></tr>

</table>

__TOC__

</StructureSection>

[[Category: Barnett, B L]]

[[Category: Delft, F Von]]

[[Category: Dunford, J E]]

[[Category: Ebetino, F H]]

[[Category: Muniz, J R.C]]

[[Category: Oppermann, U]]

[[Category: Russell, R G.G]]

[[Category: Tsoumpra, M K]]

[[Category: Walter, R L]]

[[Category: Alpha-helical prenyltransferase fold]]

[[Category: Cholesterol synthesis]]

[[Category: Dimethylallyl pyrophosphate]]

[[Category: Isopentenyl pyrophosphate]]

[[Category: Isoprene synthesis]]

[[Category: Isoprenoid pathway]]

[[Category: Lipid synthesis]]

[[Category: Steroid biosynthesis]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates==
+<StructureSection load='4nua' size='340' side='right' caption='[[4nua]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
-The entry 4nua is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4nua]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NUA FirstGlance]. <br>
-Authors: Tsoumpra, M.K., Barnett, B.L., Muniz, J.R.C., Walter, R.L., Ebetino, F.H., Von Delft, F., Russell, R.G.G., Oppermann, U., Dunford, J.E.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yq7|1yq7]], [[4ng6|4ng6]], [[4n9u|4n9u]], [[4nke|4nke]], [[4nkf|4nkf]]</td></tr>
-Description: The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nua OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nua RCSB], [http://www.ebi.ac.uk/pdbsum/4nua PDBsum]</span></td></tr>
+</table>
+__TOC__
+</StructureSection>
+[[Category: Barnett, B L]]
+[[Category: Delft, F Von]]
+[[Category: Dunford, J E]]
+[[Category: Ebetino, F H]]
+[[Category: Muniz, J R.C]]
+[[Category: Oppermann, U]]
+[[Category: Russell, R G.G]]
+[[Category: Tsoumpra, M K]]
+[[Category: Walter, R L]]
+[[Category: Alpha-helical prenyltransferase fold]]
+[[Category: Cholesterol synthesis]]
+[[Category: Dimethylallyl pyrophosphate]]
+[[Category: Isopentenyl pyrophosphate]]
+[[Category: Isoprene synthesis]]
+[[Category: Isoprenoid pathway]]
+[[Category: Lipid synthesis]]
+[[Category: Steroid biosynthesis]]
+[[Category: Transferase]]