1li4: Difference between revisions

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[[Image:1li4.gif|left|200px]]<br /><applet load="1li4" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1li4.gif|left|200px]]
caption="1li4, resolution 2.01&Aring;" />
 
'''Human S-adenosylhomocysteine hydrolase complexed with neplanocin'''<br />
{{Structure
|PDB= 1li4 |SIZE=350|CAPTION= <scene name='initialview01'>1li4</scene>, resolution 2.01&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NOC:3-(6-AMINO-PURIN-9-YL)-5-HYDROXYMETHYL-CYCLOPENTANE-1,2-DIOL'>NOC</scene> and <scene name='pdbligand=IPA:ISOPROPYL ALCOHOL'>IPA</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1]
|GENE=
}}
 
'''Human S-adenosylhomocysteine hydrolase complexed with neplanocin'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1LI4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAD:'>NAD</scene>, <scene name='pdbligand=NOC:'>NOC</scene> and <scene name='pdbligand=IPA:'>IPA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LI4 OCA].  
1LI4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LI4 OCA].  


==Reference==
==Reference==
Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions., Yang X, Hu Y, Yin DH, Turner MA, Wang M, Borchardt RT, Howell PL, Kuczera K, Schowen RL, Biochemistry. 2003 Feb 25;42(7):1900-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12590576 12590576]
Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions., Yang X, Hu Y, Yin DH, Turner MA, Wang M, Borchardt RT, Howell PL, Kuczera K, Schowen RL, Biochemistry. 2003 Feb 25;42(7):1900-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12590576 12590576]
[[Category: Adenosylhomocysteinase]]
[[Category: Adenosylhomocysteinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: inhibitor complex]]
[[Category: inhibitor complex]]


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