3ee8: Difference between revisions

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[[Image:3ee8.png|left|200px]]
==Structure of NS1 effector domain==
<StructureSection load='3ee8' size='340' side='right' caption='[[3ee8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ee8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EE8 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ee9|3ee9]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ee8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ee8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ee8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ee8 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The nonstructural protein NS1A from influenza virus is a multifunctional virulence factor and a potent inhibitor of host immunity. It has two functional domains: an N-terminal 73-amino-acid RNA-binding domain and a C-terminal effector domain. Here, the crystallographic structure of the NS1A effector domain of influenza A/Udorn/72 virus is presented. Structure comparison with the NS1 effector domain from mouse-adapted influenza A/Puerto Rico/8/34 (PR8) virus strain reveals a similar monomer conformation but a different dimer interface. Further analysis and evaluation shows that the dimer interface observed in the structure of the PR8 NS1 effector domain is likely to be a crystallographic packing effect. A hypothetical model of the intact NS1 dimer is presented.


{{STRUCTURE_3ee8|  PDB=3ee8  |  SCENE=  }}
Structure of NS1A effector domain from the influenza A/Udorn/72 virus.,Xia S, Monzingo AF, Robertus JD Acta Crystallogr D Biol Crystallogr. 2009 Jan;65(Pt 1):11-7. Epub 2008 Dec, 18. PMID:19153461<ref>PMID:19153461</ref>


===Structure of NS1 effector domain===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_19153461}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3ee8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE8 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:019153461</ref><references group="xtra"/>
[[Category: Viruses]]
[[Category: Viruses]]
[[Category: Monzingo, A F.]]
[[Category: Monzingo, A F]]
[[Category: Robertus, J D.]]
[[Category: Robertus, J D]]
[[Category: Xia, S.]]
[[Category: Xia, S]]
[[Category: Host-virus interaction]]
[[Category: Host-virus interaction]]
[[Category: Interferon antiviral system evasion]]
[[Category: Interferon antiviral system evasion]]
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