1lm7: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1lm7.gif|left|200px]] | [[Image:1lm7.gif|left|200px]] | ||
'''Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure''' | {{Structure | ||
|PDB= 1lm7 |SIZE=350|CAPTION= <scene name='initialview01'>1lm7</scene>, resolution 3.00Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure''' | |||
==Overview== | ==Overview== | ||
| Line 10: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
1LM7 is a [ | 1LM7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LM7 OCA]. | ||
==Reference== | ==Reference== | ||
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure., Choi HJ, Park-Snyder S, Pascoe LT, Green KJ, Weis WI, Nat Struct Biol. 2002 Aug;9(8):612-20. PMID:[http:// | Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure., Choi HJ, Park-Snyder S, Pascoe LT, Green KJ, Weis WI, Nat Struct Biol. 2002 Aug;9(8):612-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12101406 12101406] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 23: | Line 32: | ||
[[Category: plakin repeat]] | [[Category: plakin repeat]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:32:31 2008'' | ||
Revision as of 10:32, 20 March 2008
| |||||||||||||
| 1lm7, resolution 3.00Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure
Overview
Desmosomes are intercellular junctions in which cadherin cell adhesion molecules are linked to the intermediate filament (IF) system. Desmoplakin is a member of the plakin family of IF-binding proteins. The C-terminal domain of desmoplakin (DPCT) mediates binding to IFs in desmosomes. The DPCT sequence contains three regions, termed A, B and C, consisting of 4.5 copies of a 38-amino acid repeat motif. We demonstrate that these regions form discrete subdomains that bind to IFs and report the crystal structures of domains B and C. In contrast to the elongated structures formed by other kinds of repeat motifs, the plakin repeats form a globular structure with a unique fold. A conserved basic groove found on the domain may represent an IF-binding site.
Disease
Known diseases associated with this structure: Arrhythmogenic right ventricular dysplasia 8 OMIM:[125647], Dilated cardiomyopathy with woolly hair and keratoderma OMIM:[125647], Epidermolysis bullosa, lethal acantholytic OMIM:[125647], Keratosis palmoplantaris striata II OMIM:[125647], Skin fragility-woolly hair syndrome OMIM:[125647]
About this Structure
1LM7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure., Choi HJ, Park-Snyder S, Pascoe LT, Green KJ, Weis WI, Nat Struct Biol. 2002 Aug;9(8):612-20. PMID:12101406
Page seeded by OCA on Thu Mar 20 12:32:31 2008
