Exosome

Exosome

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D The exosome complex (the exosome) is a multi-protein complex capable of degrading various types of RNA molecules. Function Exosome Disease Autoimmunity The exosome complex is the target of autoantibodies, which are known to be found in people that suffer from various autoimmune diseases (especially PM/Scl overlap syndrome). In the autoimune diseases, antibodies are mainly directed against two of the proteins of the complex, called PM/Scl-100 and PM/Scl-75. Cancer treatment The Exosome is found to be inhibited by a cancer chemotherapy drug, which called antimetabolite fluorouracil. This drug is one of the most successful drugs for treating solid tumors. Structural highlights The core of the Exosom complex is made of a ring, which consisting of six RNases proteins (Rnase PH-like proteins). 12

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Nitzan Dubovski, Michal Harel