Molecular Playground/DnaK: Difference between revisions

Since Hsp70s are critically positioned in the proteostasis system of many organisms, including humans, they represent a tempting target for anti-cancer and neurodegenerative disease therapies. Recent efforts to develop a competitive inhibitor for Hsp70s, using DnaK as a model system, have met with only marginal success.[http://www.ncbi.nlm.nih.gov/pubmed/24312699] Recently, interactions between Hsp70s and its co-chaperones have been targeted for drug development, but with no leads currently in clinical trials.[http://www.ncbi.nlm.nih.gov/pubmed/22920901]